Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies

Roy van der Meel, William M. Gallagher, Sabrina Oliveira, Aisling E. O'Connor, Raymond M. Schiffelers, Annette T. Byrne

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)

Abstract

Molecular imaging is the visualization, characterization and measurement of biological processes at the molecular and cellular level. In oncology, molecular imaging approaches can be directly applied as translational biomarkers of disease progression. In this article, selected imaging modalities are discussed with respect to this role. Recent studies focusing on emerging imaging biomarkers and new developments in the field are highlighted. Importantly, because ex vivo or tissue-based imaging now represents an important tool in the discovery and validation of oncology biomarkers, special attention is given to this resurgent field.

Original languageEnglish
Pages (from-to)102-114
Number of pages13
JournalDrug Discovery Today
Volume15
Issue number3-4
DOIs
Publication statusPublished - 1 Feb 2010
Externally publishedYes

Keywords

  • Animals
  • Biomarkers, Tumor
  • Disease Progression
  • Humans
  • Molecular Imaging/methods
  • Neoplasms/diagnosis
  • Radionuclide Imaging
  • Translational Medical Research/methods
  • Validation Studies as Topic

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