Abstract
The development of Vasculature-on-Chip has progressed rapidly over the last decade and recently, a wealth of fabrication possibilities has emerged that can be used for engineering vessels on a chip. All these fabrication methods have their own advantages and disadvantages but, more importantly, the capability of recapitulating the in vivo vasculature differs greatly between them. The first part of this review discusses the biological background of the in vivo vasculature and all the associated processes. We then evaluate the biological relevance of different fabrication methods proposed for Vasculature-on-Chip, we indicate their possibilities and limitations, and we assess which fabrication methods are capable of recapitulating the intrinsic complexity of the vasculature. This review illustrates the complexity involved in developing in vitro vasculature and provides an overview of fabrication methods for Vasculature-on-Chip in relation to the biological relevance of such methods.
Original language | English |
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Article number | 7010017 |
Number of pages | 18 |
Journal | Bioengineering |
Volume | 7 |
Issue number | 1 |
DOIs | |
Publication status | Published - Mar 2020 |
Funding
Funding: This work is part of the research programme LOCATE with project number 15282, which is financed by the Dutch Research Council (NWO-TTW).
Funders | Funder number |
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Netherlands Organisation for Applied Scientific Research | |
Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
Keywords
- Angiogenesis
- Microfabrication
- Microfluidics
- Organ-on-chip
- Vasculature
- Vasculogenesis