Real-time feedback control of lifetec group's cardiac biosimulator based on averaged hemodynamics

Ivar de Vries; Mircea Lazar; Mattia D'Alessi; Marco Stijnen

doi:10.1016/j.ifacol.2021.10.309

Real-time feedback control of lifetec group's cardiac biosimulator based on averaged hemodynamics

Ivar de Vries, Mircea Lazar, Mattia D'Alessi, Marco Stijnen

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Abstract

LifeTec Group has developed a Cardiac Biosimulator where a dead porcine heart is used to mimic a beating heart in a simulated environment. This is useful for assessment of medical devices or as a training platform for medical professionals. The research presented aims at extending this simulator by designing feedback controllers for the time-averaged relevant pressures and flow, which reduces the startup time and potentially increases stability of the simulator. To achieve this, both the continuous and time-averaged models of the simulator are presented together with their state-space representations. The proposed controller consists of three independent PI controllers, which are presented along with simulation and measurement results and show promising system performance. Lastly, the controller implementation was tested on the Biosimulator with a pathological heart (Mitral prolapse), which showed no significant decrease in performance compared to the physiological heart.

Original language	English
Pages (from-to)	520-525
Number of pages	6
Journal	IFAC-PapersOnLine
Volume	54
Issue number	15
DOIs	https://doi.org/10.1016/j.ifacol.2021.10.309
Publication status	Published - 2021
Event	11th IFAC Symposium on Biological and Medical Systems BMS 2021 - Ghent, Belgium Duration: 19 Sept 2021 → 22 Sept 2021

Bibliographical note

Funding Information:
This research flas partly funded by the Stimuleringsfonds grant from Metropoolregio Eindhoven. LifeTec Group gratefully acknoflledges this financial support.

Funding

This research flas partly funded by the Stimuleringsfonds grant from Metropoolregio Eindhoven. LifeTec Group gratefully acknoflledges this financial support.

Keywords

Average models for electrical circuits
Beating heart
Cardiac Biosimulators
Control of physiological variables
Digital PID
Ex vivo platform
Model formulation

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10.1016/j.ifacol.2021.10.309

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title = "Real-time feedback control of lifetec group's cardiac biosimulator based on averaged hemodynamics",

abstract = "LifeTec Group has developed a Cardiac Biosimulator where a dead porcine heart is used to mimic a beating heart in a simulated environment. This is useful for assessment of medical devices or as a training platform for medical professionals. The research presented aims at extending this simulator by designing feedback controllers for the time-averaged relevant pressures and flow, which reduces the startup time and potentially increases stability of the simulator. To achieve this, both the continuous and time-averaged models of the simulator are presented together with their state-space representations. The proposed controller consists of three independent PI controllers, which are presented along with simulation and measurement results and show promising system performance. Lastly, the controller implementation was tested on the Biosimulator with a pathological heart (Mitral prolapse), which showed no significant decrease in performance compared to the physiological heart.",

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author = "{de Vries}, Ivar and Mircea Lazar and Mattia D'Alessi and Marco Stijnen",

note = "Funding Information: This research flas partly funded by the Stimuleringsfonds grant from Metropoolregio Eindhoven. LifeTec Group gratefully acknoflledges this financial support. ; 11th IFAC Symposium on Biological and Medical Systems BMS 2021 ; Conference date: 19-09-2021 Through 22-09-2021",

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AU - Lazar, Mircea

AU - D'Alessi, Mattia

AU - Stijnen, Marco

N1 - Funding Information: This research flas partly funded by the Stimuleringsfonds grant from Metropoolregio Eindhoven. LifeTec Group gratefully acknoflledges this financial support.

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N2 - LifeTec Group has developed a Cardiac Biosimulator where a dead porcine heart is used to mimic a beating heart in a simulated environment. This is useful for assessment of medical devices or as a training platform for medical professionals. The research presented aims at extending this simulator by designing feedback controllers for the time-averaged relevant pressures and flow, which reduces the startup time and potentially increases stability of the simulator. To achieve this, both the continuous and time-averaged models of the simulator are presented together with their state-space representations. The proposed controller consists of three independent PI controllers, which are presented along with simulation and measurement results and show promising system performance. Lastly, the controller implementation was tested on the Biosimulator with a pathological heart (Mitral prolapse), which showed no significant decrease in performance compared to the physiological heart.

AB - LifeTec Group has developed a Cardiac Biosimulator where a dead porcine heart is used to mimic a beating heart in a simulated environment. This is useful for assessment of medical devices or as a training platform for medical professionals. The research presented aims at extending this simulator by designing feedback controllers for the time-averaged relevant pressures and flow, which reduces the startup time and potentially increases stability of the simulator. To achieve this, both the continuous and time-averaged models of the simulator are presented together with their state-space representations. The proposed controller consists of three independent PI controllers, which are presented along with simulation and measurement results and show promising system performance. Lastly, the controller implementation was tested on the Biosimulator with a pathological heart (Mitral prolapse), which showed no significant decrease in performance compared to the physiological heart.

KW - Average models for electrical circuits

KW - Beating heart

KW - Cardiac Biosimulators

KW - Control of physiological variables

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KW - Ex vivo platform

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Real-time feedback control of lifetec group's cardiac biosimulator based on averaged hemodynamics

Abstract

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Keywords

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