Abstract
I can see clearly now: Bicyclo[6.1.0]non-4-yne, an easily prepared, symmetrical cycloalkyne, displays excellent reaction kinetics in strain-promoted cycloaddition reactions with azides and nitrones (see scheme). Highly specific protein modifications are demonstrated in vitro and subcellular-resolved imaging of glycan expression was achieved in metastatic melanoma cells during invasive migration into three-dimensional collagen lattices.
Original language | English |
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Pages (from-to) | 9422-9425 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 49 |
Issue number | 49 |
DOIs | |
Publication status | Published - 3 Dec 2010 |
Externally published | Yes |
Keywords
- cycloadditions
- cycloalkynes
- imaging
- kinetics
- protein modification