Radiochemistry on chip : towards dose-on-demand synthesis of PET radiopharmaceuticals

V. Arima, G. Pascali, O. Lade, H.R. Kretschmer, I. Bernsdorf, V. Hammond, P. Watts, F. De Leonardis, M.D. Tarn, N. Pamme, B.Z. Cvetkovic, P.S. Dittrich, N. Vasovic, R. Duane, A. Jaksic, A. Zacheo, A. Zizzari, L. Marra, E. Perrone, P.A. SalvadoriR. Rinaldi

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)
2 Downloads (Pure)

Abstract

We have developed an integrated microfluidic platform for producing 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40–80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals.
Original languageEnglish
Pages (from-to)2328-2336
Number of pages9
JournalLab on a Chip
Volume13
Issue number12
DOIs
Publication statusPublished - 2013

Fingerprint

Dive into the research topics of 'Radiochemistry on chip : towards dose-on-demand synthesis of PET radiopharmaceuticals'. Together they form a unique fingerprint.

Cite this