Racemization-free synthesis of S-alkylated cysteines via thiol-ene reaction

G. Triola; L. Brunsveld; H. Waldmann

doi:10.1021/jo800198s

Racemization-free synthesis of S-alkylated cysteines via thiol-ene reaction

G. Triola, L. Brunsveld, H. Waldmann

Chemical Biology

Research output: Contribution to journal › Article › Academic › peer-review

57 Citations (Scopus)

Abstract

Treatment of differently protected and unprotected cysteines with a variety of alkenes in the presence of a radical initiator (AIBN) afforded the corresponding S-alkylated cysteines in high yields and without racemization.

Original language	English
Pages (from-to)	3646-3649
Journal	Journal of Organic Chemistry
Volume	73
Issue number	9
DOIs	https://doi.org/10.1021/jo800198s
Publication status	Published - 2008

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title = "Racemization-free synthesis of S-alkylated cysteines via thiol-ene reaction",

abstract = "Treatment of differently protected and unprotected cysteines with a variety of alkenes in the presence of a radical initiator (AIBN) afforded the corresponding S-alkylated cysteines in high yields and without racemization.",

author = "G. Triola and L. Brunsveld and H. Waldmann",

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doi = "10.1021/jo800198s",

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journal = "Journal of Organic Chemistry",

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AU - Brunsveld, L.

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N2 - Treatment of differently protected and unprotected cysteines with a variety of alkenes in the presence of a radical initiator (AIBN) afforded the corresponding S-alkylated cysteines in high yields and without racemization.

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U2 - 10.1021/jo800198s

DO - 10.1021/jo800198s

M3 - Article

C2 - 18376863

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VL - 73

SP - 3646

EP - 3649

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 9

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Racemization-free synthesis of S-alkylated cysteines via thiol-ene reaction

Abstract

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