Quantitative, multi-institutional evaluation of MR thermometry accuracy for deep-pelvic MR-hyperthermia systems operating in multi-vendor MR-systems using a new anthropomorphic phantom

Sergio Curto (Corresponding author), Bassim Aklan, Tim Mulder, Oliver Mils, Manfred Schmidt, Ulf Lamprecht, Michael Peller, Ruediger Wessalowski, Lars H. Lindner, Rainer Fietkau, Daniel Zips, Gennaro G. Bellizzi, Netteke van Holthe, Martine Franckena, Margarethus M. Paulides, Gerard C. van Rhoon

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
34 Downloads (Pure)

Abstract

Clinical outcome of hyperthermia depends on the achieved target temperature, therefore target conformal heating is essential. Currently, invasive temperature probe measurements are the gold standard for temperature monitoring, however, they only provide limited sparse data. In contrast, magnetic resonance thermometry (MRT) provides unique capabilities to non--invasively measure the 3D--temperature. This study investigates MRT accuracy for MR--hyperthermia hybrid systems located at five European institutions while heating a centric or eccentric target in anthropomorphic phantoms with pelvic and spine structures. Scatter plots, root mean square error (RMSE) and Bland–Altman analysis were used to quantify accuracy of MRT compared to high resistance thermistor probe measurements. For all institutions, a linear relation between MRT and thermistor probes measurements was found with R2 (mean ± standard deviation) of 0.97 ± 0.03 and 0.97 ± 0.02, respectively for centric and eccentric heating targets. The RMSE was found to be 0.52 ± 0.31 °C and 0.30 ± 0.20 °C, respectively. The Bland--Altman evaluation showed a mean difference of 0.46 ± 0.20 °C and 0.13 ± 0.08 °C, respectively. This first multi--institutional evaluation of MR-hyperthermia hybrid systems indicates comparable device performance and good agreement between MRT and thermistor probes measurements. This forms the basis to standardize treatments in multi--institution studies of MR--guided hyperthermia and to elucidate thermal dose--effect relations.

Original languageEnglish
Article number1709
Number of pages19
JournalCancers
Volume11
Issue number11
DOIs
Publication statusPublished - 2 Nov 2019

Keywords

  • Anthropomorphic phantom
  • Magnetic resonance imaging--guided hyperthermia
  • Magnetic resonance thermometry
  • Quality assurance
  • Radiofrequency hyperthermia
  • Thermistor probe

Fingerprint Dive into the research topics of 'Quantitative, multi-institutional evaluation of MR thermometry accuracy for deep-pelvic MR-hyperthermia systems operating in multi-vendor MR-systems using a new anthropomorphic phantom'. Together they form a unique fingerprint.

Cite this