Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis

N. Melikian; S. Vercauteren; W.F. Fearon; T. Cuisset; P.A. MacCarthy; G. Davidavicius; W.H. Aarnoudse; J. Bartunek; M. Vanderheyden; E. Wyffels; W. Wijns; G.R. Heyndrickx; N.H.J. Pijls; B. Bruyne, de

Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis

N. Melikian, S. Vercauteren, W.F. Fearon, T. Cuisset, P.A. MacCarthy, G. Davidavicius, W.H. Aarnoudse, J. Bartunek, M. Vanderheyden, E. Wyffels, W. Wijns, G.R. Heyndrickx, N.H.J. Pijls, B. Bruyne, de

Research output: Contribution to journal › Article › Academic › peer-review

104 Citations (Scopus)

Abstract

AIMS: The influence of atherosclerosis and its risk factors on coronary microvascular function remain unclear as current methods of assessing microvascular function do not specifically test the microcirculation in isolation. We examined the influence of epicardial vessel atherosclerosis on coronary microvascular function using the index of myocardial resistance (IMR). METHODS AND RESULTS: IMR (a measure of microvascular function) and fractional flow reserve (FFR, a measure of the epicardial compartment) were measured in 143 coronary arteries (116 patients). Fifteen patients (22 arteries, mean age 48+/-16 years) had no clinical evidence of atherosclerosis (control group). One hundred and one patients (121 arteries, mean age 63+/-11 years) had established atherosclerosis and multiple cardiovascular risk factors (atheroma group). Mean IMR in the control group (19+/-5, range 8-28) was significantly lower than in the atheroma group (25+/-13, range 6-75) (P

Original language	English
Pages (from-to)	939-945
Journal	EuroIntervention
Volume	5
Issue number	8
Publication status	Published - 2010

Cite this

Melikian, N., Vercauteren, S., Fearon, W. F., Cuisset, T., MacCarthy, P. A., Davidavicius, G., Aarnoudse, W. H., Bartunek, J., Vanderheyden, M., Wyffels, E., Wijns, W., Heyndrickx, G. R., Pijls, N. H. J., & Bruyne, de, B. (2010). Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis. EuroIntervention, 5(8), 939-945.

@article{5acf4340c8e14dc4b8fbab432b64a896,

title = "Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis",

abstract = "AIMS: The influence of atherosclerosis and its risk factors on coronary microvascular function remain unclear as current methods of assessing microvascular function do not specifically test the microcirculation in isolation. We examined the influence of epicardial vessel atherosclerosis on coronary microvascular function using the index of myocardial resistance (IMR). METHODS AND RESULTS: IMR (a measure of microvascular function) and fractional flow reserve (FFR, a measure of the epicardial compartment) were measured in 143 coronary arteries (116 patients). Fifteen patients (22 arteries, mean age 48+/-16 years) had no clinical evidence of atherosclerosis (control group). One hundred and one patients (121 arteries, mean age 63+/-11 years) had established atherosclerosis and multiple cardiovascular risk factors (atheroma group). Mean IMR in the control group (19+/-5, range 8-28) was significantly lower than in the atheroma group (25+/-13, range 6-75) (P",

author = "N. Melikian and S. Vercauteren and W.F. Fearon and T. Cuisset and P.A. MacCarthy and G. Davidavicius and W.H. Aarnoudse and J. Bartunek and M. Vanderheyden and E. Wyffels and W. Wijns and G.R. Heyndrickx and N.H.J. Pijls and {Bruyne, de}, B.",

year = "2010",

language = "English",

volume = "5",

pages = "939--945",

journal = "EuroIntervention",

issn = "1774-024X",

publisher = "Europa Group",

number = "8",

}

TY - JOUR

T1 - Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis

AU - Melikian, N.

AU - Vercauteren, S.

AU - Fearon, W.F.

AU - Cuisset, T.

AU - MacCarthy, P.A.

AU - Davidavicius, G.

AU - Aarnoudse, W.H.

AU - Bartunek, J.

AU - Vanderheyden, M.

AU - Wyffels, E.

AU - Wijns, W.

AU - Heyndrickx, G.R.

AU - Pijls, N.H.J.

AU - Bruyne, de, B.

PY - 2010

Y1 - 2010

N2 - AIMS: The influence of atherosclerosis and its risk factors on coronary microvascular function remain unclear as current methods of assessing microvascular function do not specifically test the microcirculation in isolation. We examined the influence of epicardial vessel atherosclerosis on coronary microvascular function using the index of myocardial resistance (IMR). METHODS AND RESULTS: IMR (a measure of microvascular function) and fractional flow reserve (FFR, a measure of the epicardial compartment) were measured in 143 coronary arteries (116 patients). Fifteen patients (22 arteries, mean age 48+/-16 years) had no clinical evidence of atherosclerosis (control group). One hundred and one patients (121 arteries, mean age 63+/-11 years) had established atherosclerosis and multiple cardiovascular risk factors (atheroma group). Mean IMR in the control group (19+/-5, range 8-28) was significantly lower than in the atheroma group (25+/-13, range 6-75) (P

AB - AIMS: The influence of atherosclerosis and its risk factors on coronary microvascular function remain unclear as current methods of assessing microvascular function do not specifically test the microcirculation in isolation. We examined the influence of epicardial vessel atherosclerosis on coronary microvascular function using the index of myocardial resistance (IMR). METHODS AND RESULTS: IMR (a measure of microvascular function) and fractional flow reserve (FFR, a measure of the epicardial compartment) were measured in 143 coronary arteries (116 patients). Fifteen patients (22 arteries, mean age 48+/-16 years) had no clinical evidence of atherosclerosis (control group). One hundred and one patients (121 arteries, mean age 63+/-11 years) had established atherosclerosis and multiple cardiovascular risk factors (atheroma group). Mean IMR in the control group (19+/-5, range 8-28) was significantly lower than in the atheroma group (25+/-13, range 6-75) (P

M3 - Article

SN - 1774-024X

VL - 5

SP - 939

EP - 945

JO - EuroIntervention

JF - EuroIntervention

IS - 8

ER -

Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis

Abstract

Fingerprint

Cite this