Proteinuria precedes cerebral edema in stroke-prone rats : a magnetic resonance imaging study

E.L.A. Blezer, M. Schurink, K. Nicolaij, P.R. Dop Bär, G.H. Jansen, H.A. Koomans, Jaap Joles

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)

Abstract

Background and Purpose: Stroke-prone spontaneously hypertensive rats (SHRSP) subjected to high sodium intake develop severe hypertension, cerebral edema, and proteinuria, culminating in organ damage and early death. MRI, which can be applied serially, provides the unique opportunity to study temporal and quantitative relations between these changes and whether diminution of sodium intake can attenuate established cerebral edema.
Original languageEnglish
Pages (from-to)167-174
JournalStroke : a Journal of Celebral Circulation
Volume29
Issue number1
DOIs
Publication statusPublished - 1998

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