Protein-protein interactions as drug targets

M. Skwarczynska, C. Ottmann

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)


Modulation of protein–protein interactions (PPIs) is becoming increasingly important in drug discovery and chemical biology. While a few years ago this ‘target class’ was deemed to be largely undruggable an impressing number of publications and success stories now show that targeting PPIs with small, drug-like molecules indeed is a feasible approach. Here, we summarize the current state of small-molecule inhibition and stabilization of PPIs and review the active molecules from a structural and medicinal chemistry angle, especially focusing on the key examples of iNOS, LFA-1 and 14–3–3.
Original languageEnglish
Article number16
Pages (from-to)2195-2219
JournalFuture Medicinal Chemistry
Issue number16
Publication statusPublished - 1 Oct 2015


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