Protein modification by strain-promoted alkyne-azide cycloaddition

J.C.M. Hest, van; F.L. van Delft

doi:10.1002/cbic.201100206

Protein modification by strain-promoted alkyne-azide cycloaddition

J.C.M. Hest, van
, F.L. van Delft

Research output: Contribution to journal › Article › Academic › peer-review

51 Citations (Scopus)

Abstract

Taking the strain: Strain-promoted cycloadditions between alkynes and azides have facilitated mild and bioorthogonal protein modification. Azides can be introduced into a protein by a variety of chemical, enzymatic or genetic techniques. Now genetic encoding of a cyclooctyne offers new opportunities for protein modification and the study of proteins in their native habitat.

Original language	English
Pages (from-to)	1309-1312
Number of pages	4
Journal	ChemBioChem
Volume	12
Issue number	9
DOIs	https://doi.org/10.1002/cbic.201100206
Publication status	Published - 14 Jun 2011
Externally published	Yes

Keywords

Azides
Bioorthogonal chemistry
Cycloadditions
Cyclooctynes
Protein modification

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10.1002/cbic.201100206

Cite this

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abstract = "Taking the strain: Strain-promoted cycloadditions between alkynes and azides have facilitated mild and bioorthogonal protein modification. Azides can be introduced into a protein by a variety of chemical, enzymatic or genetic techniques. Now genetic encoding of a cyclooctyne offers new opportunities for protein modification and the study of proteins in their native habitat.",

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AB - Taking the strain: Strain-promoted cycloadditions between alkynes and azides have facilitated mild and bioorthogonal protein modification. Azides can be introduced into a protein by a variety of chemical, enzymatic or genetic techniques. Now genetic encoding of a cyclooctyne offers new opportunities for protein modification and the study of proteins in their native habitat.

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KW - Bioorthogonal chemistry

KW - Cycloadditions

KW - Cyclooctynes

KW - Protein modification

UR - https://www.scopus.com/pages/publications/79958763426

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Protein modification by strain-promoted alkyne-azide cycloaddition

Abstract

Keywords

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