Threading collagen through a protein needle: The collagen-binding protein CNA35 operates by wrapping itself around the collagen triple helix. By connecting the N and C termini through an MMP recognition sequence, a dual-specific MMP-sensitive collagen-targeting ligand is obtained that can be used for imaging extracellular matrix turnover.
|Number of pages||4|
|Publication status||Published - 2010|
- Matrix metalloproteinases (MMP)
- Molecular imaging
- Molecular recognition
- Protein engineering