Protease-activatable collagen targeting based on protein cyclization

M. Breurken, E.H.M. Lempens, M. Merkx

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Threading collagen through a protein needle: The collagen-binding protein CNA35 operates by wrapping itself around the collagen triple helix. By connecting the N and C termini through an MMP recognition sequence, a dual-specific MMP-sensitive collagen-targeting ligand is obtained that can be used for imaging extracellular matrix turnover.
Original languageEnglish
Pages (from-to)1665-1668
JournalChemBioChem
Volume11
Issue number12
DOIs
Publication statusPublished - 2010

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