Protease-activatable collagen targeting based on protein cyclization

M. Breurken; E.H.M. Lempens; M. Merkx

doi:10.1002/cbic.201000223

Protease-activatable collagen targeting based on protein cyclization

M. Breurken, E.H.M. Lempens, M. Merkx

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

Threading collagen through a protein needle: The collagen-binding protein CNA35 operates by wrapping itself around the collagen triple helix. By connecting the N and C termini through an MMP recognition sequence, a dual-specific MMP-sensitive collagen-targeting ligand is obtained that can be used for imaging extracellular matrix turnover.

Original language	English
Pages (from-to)	1665-1668
Number of pages	4
Journal	ChemBioChem
Volume	11
Issue number	12
DOIs	https://doi.org/10.1002/cbic.201000223
Publication status	Published - 2010

Keywords

Collagen
Matrix metalloproteinases (MMP)
Molecular imaging
Molecular recognition
Protein engineering

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10.1002/cbic.201000223

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title = "Protease-activatable collagen targeting based on protein cyclization",

abstract = "Threading collagen through a protein needle: The collagen-binding protein CNA35 operates by wrapping itself around the collagen triple helix. By connecting the N and C termini through an MMP recognition sequence, a dual-specific MMP-sensitive collagen-targeting ligand is obtained that can be used for imaging extracellular matrix turnover.",

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AU - Lempens, E.H.M.

AU - Merkx, M.

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KW - Molecular imaging

KW - Molecular recognition

KW - Protein engineering

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JO - ChemBioChem

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Protease-activatable collagen targeting based on protein cyclization

Abstract

Keywords

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