Properties of cyclodextrins. II. Preparation of a stable β-cyclodextrin hydrate and determination of its water content and enthalpy of solution in water from 15 to 30.deg

N. Wiedenhof, J.N.J.J. Lammers

    Research output: Contribution to journalArticleAcademicpeer-review

    6 Citations (Scopus)
    2 Downloads (Pure)

    Abstract

    The solubility of ß-cyclodextrin (ß-CD) in water has been measured by a refractive-index method at 15–30°. Evidence was obtained that the same, solid ß-CD hydrate phase is present in this temperature range. The formula of the hydrate was shown to be C42H70O35(12.0 ± 0.5)H20. A method for preparation of this ß-CD hydrate is described. The relations between refractive index and concentration of ß-CD are given. The calculated enthalpy of solution ¿H50l = 7.094 ±0.021 kcal. mole-1. This value will only slightly be influenced by the number of moles of water per mole of ß-CD in the hydrated solid. The solubility of ß-CD as a function of temperature can be described by 2.303 log10 m = (3.88±0.02) - (3583±18)/T where m = mole fraction of anhydrous ß-CD at saturation, and T = absolute temperature.
    Original languageEnglish
    Pages (from-to)1-6
    Number of pages6
    JournalCarbohydrate Research
    Volume7
    Issue number1
    DOIs
    Publication statusPublished - 1968

    Fingerprint

    Dive into the research topics of 'Properties of cyclodextrins. II. Preparation of a stable β-cyclodextrin hydrate and determination of its water content and enthalpy of solution in water from 15 to 30.deg'. Together they form a unique fingerprint.

    Cite this