Proof of concept of a 45-second cardiorespiratory fitness self-test for coronary artery disease patients based on accelerometry

G. Papini, A.G. Bonomi, W. Stout, Jos J. Kraal, Hareld M.C. Kemps, F. Sartor

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
136 Downloads (Pure)

Abstract

Cardiorespiratory fitness (CRF) provides important diagnostic and prognostic information. It is measured directly via laboratory maximal testing or indirectly via submaximal protocols making use of predictor parameters such as submaximal , heart rate, workload, and perceived exertion. We have established an innovative methodology, which can provide CRF prediction based only on body motion during a periodic movement. Thirty healthy subjects (40% females, 31.3 ± 7.8 yrs, 25.1 ± 3.2 BMI) and eighteen male coronary artery disease (CAD) (56.6 ± 7.4 yrs, 28.7 ± 4.0 BMI) patients performed a test on a cycle ergometer as well as a 45 second squatting protocol at a fixed tempo (80 bpm). A tri-axial accelerometer was used to monitor movements during the squat exercise test. Three regression models were developed to predict CRF based on subject characteristics and a new accelerometer-derived feature describing motion decay. For each model, the Pearson correlation coefficient and the root mean squared error percentage were calculated using the leave-one-subject-out cross-validation method (rcv, RMSEcv). The model built with all healthy individuals’ data showed an rcv = 0.68 and an RMSEcv = 16.7%. The CRF prediction improved when only healthy individuals with normal to lower fitness (CRF<40 ml/min/kg) were included, showing an rcv = 0.91 and RMSEcv = 8.7%. Finally, our accelerometry-based CRF prediction CAD patients, the majority of whom taking β-blockers, still showed high accuracy (rcv = 0.91; RMSEcv = 9.6%). In conclusion, motion decay and subject characteristics could be used to predict CRF in healthy people as well as in CAD patients taking β-blockers, accurately. This method could represent a valid alternative for patients taking β-blockers, but needs to be further validated in a larger population.
Original languageEnglish
Article numbere0183740
Number of pages13
JournalPLoS ONE
Volume12
Issue number9
DOIs
Publication statusPublished - 7 Sep 2017

Keywords

  • cardiovascular disease
  • vo2max
  • Wearable technology
  • Accelerometer
  • fitness exercise
  • Motion
  • Cardiorespiratory Fitness
  • Models, Cardiovascular
  • Humans
  • Oxygen Consumption
  • Linear Models
  • Coronary Artery Disease/diagnosis
  • Accelerometry/instrumentation
  • Aged

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