Prognosis and prognostic factors of patients with mesothelioma : a population-based study

S. Bij, van der, H. Koffijberg, J.A. Burgers, P. Baas, M.J. van de Vijver, B.A.J.M. Mol, de, K.G.M. Moons

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BACKGROUND: It is important to regularly update survival estimates of patients with malignant mesothelioma as prognosis may vary according to epidemiologic factors and diagnostic and therapeutic management. METHODS: We assessed overall (baseline) survival as well as related prognostic variables in a large cohort of 1353 patients with a confirmed diagnosis of malignant mesothelioma between 2005 and 2008. RESULTS: About 50% of the patients were 70 years or older at diagnosis and the median latency time since start of asbestos exposure was 49 years. One year after diagnosis, 47% of the patients were alive, 20% after 2 years and 15% after 3 years. Prognostic variables independently associated with worse survival were: older age (HR = 1.04 per year 95% CI (1.03-1.06)), sarcomatoid subtype (HR = 2.45 95% CI (2.06-2.90)) and non-pleural localisation (HR = 1.67 95% CI (1.26-2.22)). CONCLUSION: Survival of patients with malignant mesothelioma is still limited and depends highly on patient age, mesothelioma subtype and localisation. In addition, a substantial part of the patients had a long latency time between asbestos exposure and diagnosis. British Journal of Cancer (2012) 107, 161-164. doi: 10.1038/bjc.2012.245 Published online 29 May 2012 (C) 2012 Cancer Research UK
Original languageEnglish
Pages (from-to)161-164
JournalBritish Journal of Cancer
Issue number1
Publication statusPublished - 2012


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