Prognosis and prognostic factors of patients with mesothelioma : a population-based study

S. Bij, van der; H. Koffijberg; J.A. Burgers; P. Baas; M.J. van de Vijver; B.A.J.M. Mol, de; K.G.M. Moons

doi:10.1038/bjc.2012.245

Prognosis and prognostic factors of patients with mesothelioma : a population-based study

S. Bij, van der, H. Koffijberg, J.A. Burgers, P. Baas, M.J. van de Vijver, B.A.J.M. Mol, de, K.G.M. Moons

Cardiovascular Biomechanics

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Abstract

BACKGROUND: It is important to regularly update survival estimates of patients with malignant mesothelioma as prognosis may vary according to epidemiologic factors and diagnostic and therapeutic management. METHODS: We assessed overall (baseline) survival as well as related prognostic variables in a large cohort of 1353 patients with a confirmed diagnosis of malignant mesothelioma between 2005 and 2008. RESULTS: About 50% of the patients were 70 years or older at diagnosis and the median latency time since start of asbestos exposure was 49 years. One year after diagnosis, 47% of the patients were alive, 20% after 2 years and 15% after 3 years. Prognostic variables independently associated with worse survival were: older age (HR = 1.04 per year 95% CI (1.03-1.06)), sarcomatoid subtype (HR = 2.45 95% CI (2.06-2.90)) and non-pleural localisation (HR = 1.67 95% CI (1.26-2.22)). CONCLUSION: Survival of patients with malignant mesothelioma is still limited and depends highly on patient age, mesothelioma subtype and localisation. In addition, a substantial part of the patients had a long latency time between asbestos exposure and diagnosis. British Journal of Cancer (2012) 107, 161-164. doi: 10.1038/bjc.2012.245 www.bjcancer.com Published online 29 May 2012 (C) 2012 Cancer Research UK

Original language	English
Pages (from-to)	161-164
Journal	British Journal of Cancer
Volume	107
Issue number	1
DOIs	https://doi.org/10.1038/bjc.2012.245
Publication status	Published - 2012

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title = "Prognosis and prognostic factors of patients with mesothelioma : a population-based study",

abstract = "BACKGROUND: It is important to regularly update survival estimates of patients with malignant mesothelioma as prognosis may vary according to epidemiologic factors and diagnostic and therapeutic management. METHODS: We assessed overall (baseline) survival as well as related prognostic variables in a large cohort of 1353 patients with a confirmed diagnosis of malignant mesothelioma between 2005 and 2008. RESULTS: About 50% of the patients were 70 years or older at diagnosis and the median latency time since start of asbestos exposure was 49 years. One year after diagnosis, 47% of the patients were alive, 20% after 2 years and 15% after 3 years. Prognostic variables independently associated with worse survival were: older age (HR = 1.04 per year 95% CI (1.03-1.06)), sarcomatoid subtype (HR = 2.45 95% CI (2.06-2.90)) and non-pleural localisation (HR = 1.67 95% CI (1.26-2.22)). CONCLUSION: Survival of patients with malignant mesothelioma is still limited and depends highly on patient age, mesothelioma subtype and localisation. In addition, a substantial part of the patients had a long latency time between asbestos exposure and diagnosis. British Journal of Cancer (2012) 107, 161-164. doi: 10.1038/bjc.2012.245 www.bjcancer.com Published online 29 May 2012 (C) 2012 Cancer Research UK",

author = "{Bij, van der}, S. and H. Koffijberg and J.A. Burgers and P. Baas and {van de Vijver}, M.J. and {Mol, de}, B.A.J.M. and K.G.M. Moons",

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T1 - Prognosis and prognostic factors of patients with mesothelioma : a population-based study

AU - Bij, van der, S.

AU - Koffijberg, H.

AU - Burgers, J.A.

AU - Baas, P.

AU - van de Vijver, M.J.

AU - Mol, de, B.A.J.M.

AU - Moons, K.G.M.

PY - 2012

Y1 - 2012

N2 - BACKGROUND: It is important to regularly update survival estimates of patients with malignant mesothelioma as prognosis may vary according to epidemiologic factors and diagnostic and therapeutic management. METHODS: We assessed overall (baseline) survival as well as related prognostic variables in a large cohort of 1353 patients with a confirmed diagnosis of malignant mesothelioma between 2005 and 2008. RESULTS: About 50% of the patients were 70 years or older at diagnosis and the median latency time since start of asbestos exposure was 49 years. One year after diagnosis, 47% of the patients were alive, 20% after 2 years and 15% after 3 years. Prognostic variables independently associated with worse survival were: older age (HR = 1.04 per year 95% CI (1.03-1.06)), sarcomatoid subtype (HR = 2.45 95% CI (2.06-2.90)) and non-pleural localisation (HR = 1.67 95% CI (1.26-2.22)). CONCLUSION: Survival of patients with malignant mesothelioma is still limited and depends highly on patient age, mesothelioma subtype and localisation. In addition, a substantial part of the patients had a long latency time between asbestos exposure and diagnosis. British Journal of Cancer (2012) 107, 161-164. doi: 10.1038/bjc.2012.245 www.bjcancer.com Published online 29 May 2012 (C) 2012 Cancer Research UK

AB - BACKGROUND: It is important to regularly update survival estimates of patients with malignant mesothelioma as prognosis may vary according to epidemiologic factors and diagnostic and therapeutic management. METHODS: We assessed overall (baseline) survival as well as related prognostic variables in a large cohort of 1353 patients with a confirmed diagnosis of malignant mesothelioma between 2005 and 2008. RESULTS: About 50% of the patients were 70 years or older at diagnosis and the median latency time since start of asbestos exposure was 49 years. One year after diagnosis, 47% of the patients were alive, 20% after 2 years and 15% after 3 years. Prognostic variables independently associated with worse survival were: older age (HR = 1.04 per year 95% CI (1.03-1.06)), sarcomatoid subtype (HR = 2.45 95% CI (2.06-2.90)) and non-pleural localisation (HR = 1.67 95% CI (1.26-2.22)). CONCLUSION: Survival of patients with malignant mesothelioma is still limited and depends highly on patient age, mesothelioma subtype and localisation. In addition, a substantial part of the patients had a long latency time between asbestos exposure and diagnosis. British Journal of Cancer (2012) 107, 161-164. doi: 10.1038/bjc.2012.245 www.bjcancer.com Published online 29 May 2012 (C) 2012 Cancer Research UK

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JO - British Journal of Cancer

JF - British Journal of Cancer

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Prognosis and prognostic factors of patients with mesothelioma : a population-based study

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