Production of chemically pure gaseous [N-13]NH3 pulses for PEP studies using a modified DeVarda reduction

D.P. Sobczyk; J. Grondelle, van; A.M. Jong, de; M.J.A. Voigt, de; R.A. Santen, van

doi:10.1016/S0969-8043(02)00094-5

Production of chemically pure gaseous [N-13]NH3 pulses for PEP studies using a modified DeVarda reduction

D.P. Sobczyk
, J. Grondelle, van
, A.M. Jong, de
, M.J.A. Voigt, de
, R.A. Santen, van

Research output: Contribution to journal › Article › Academic › peer-review

12 Citations (Scopus)

Abstract

A fast and reproducible production method for pure gaseous [13N]NH3 pulses has been developed. 13N was produced by irradiation of water with 500 nA of 16 MeV protons via the 16O(p,α)13N reaction. A mixture of DeVarda's alloy and NaOH was used to convert the produced nitrate/nitrite to ammonia. Pre-treatment of this mixture with water increased the concentrated production of gaseous [13N]NH3. Separation and further purification of ammonia were performed with GC, leading to 5 s pulses (1.1 ml STP) with 3.5±0.5 MBq [13N]NH3 with a high chemical and radiochemical purity suited for positron emission profiling (PEP).

Original language	English
Pages (from-to)	201-207
Journal	Applied Radiation and Isotopes
Volume	57
Issue number	2
DOIs	https://doi.org/10.1016/S0969-8043(02)00094-5
Publication status	Published - 2002

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title = "Production of chemically pure gaseous [N-13]NH3 pulses for PEP studies using a modified DeVarda reduction",

abstract = "A fast and reproducible production method for pure gaseous [13N]NH3 pulses has been developed. 13N was produced by irradiation of water with 500 nA of 16 MeV protons via the 16O(p,α)13N reaction. A mixture of DeVarda's alloy and NaOH was used to convert the produced nitrate/nitrite to ammonia. Pre-treatment of this mixture with water increased the concentrated production of gaseous [13N]NH3. Separation and further purification of ammonia were performed with GC, leading to 5 s pulses (1.1 ml STP) with 3.5±0.5 MBq [13N]NH3 with a high chemical and radiochemical purity suited for positron emission profiling (PEP).",

author = "D.P. Sobczyk and \{Grondelle, van\}, J. and \{Jong, de\}, A.M. and \{Voigt, de\}, M.J.A. and \{Santen, van\}, R.A.",

year = "2002",

doi = "10.1016/S0969-8043(02)00094-5",

language = "English",

volume = "57",

pages = "201--207",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

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TY - JOUR

T1 - Production of chemically pure gaseous [N-13]NH3 pulses for PEP studies using a modified DeVarda reduction

AU - Sobczyk, D.P.

AU - Grondelle, van, J.

AU - Jong, de, A.M.

AU - Voigt, de, M.J.A.

AU - Santen, van, R.A.

PY - 2002

Y1 - 2002

N2 - A fast and reproducible production method for pure gaseous [13N]NH3 pulses has been developed. 13N was produced by irradiation of water with 500 nA of 16 MeV protons via the 16O(p,α)13N reaction. A mixture of DeVarda's alloy and NaOH was used to convert the produced nitrate/nitrite to ammonia. Pre-treatment of this mixture with water increased the concentrated production of gaseous [13N]NH3. Separation and further purification of ammonia were performed with GC, leading to 5 s pulses (1.1 ml STP) with 3.5±0.5 MBq [13N]NH3 with a high chemical and radiochemical purity suited for positron emission profiling (PEP).

AB - A fast and reproducible production method for pure gaseous [13N]NH3 pulses has been developed. 13N was produced by irradiation of water with 500 nA of 16 MeV protons via the 16O(p,α)13N reaction. A mixture of DeVarda's alloy and NaOH was used to convert the produced nitrate/nitrite to ammonia. Pre-treatment of this mixture with water increased the concentrated production of gaseous [13N]NH3. Separation and further purification of ammonia were performed with GC, leading to 5 s pulses (1.1 ml STP) with 3.5±0.5 MBq [13N]NH3 with a high chemical and radiochemical purity suited for positron emission profiling (PEP).

U2 - 10.1016/S0969-8043(02)00094-5

DO - 10.1016/S0969-8043(02)00094-5

M3 - Article

SN - 0969-8043

VL - 57

SP - 201

EP - 207

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 2

ER -

Production of chemically pure gaseous [N-13]NH3 pulses for PEP studies using a modified DeVarda reduction

Abstract

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