Process intensification in a microwave heated fine-chemical milli-plant at large scale operation

F. Benaskar, E. Rebrov, N.G. Patil, J. Meuldijk, L.A. Hulshof, V. Hessel, J.C. Schouten

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Abstract

The integration of micro reactor technology and microwave heating has been investigated for two important classes of fine-chemical reactions, leading to improved catalyst surface and selective catalyst heating. A wall-coated micro reactor and a micro fixed-bed millireactor were designed and applied in the Ullmann-type C-O coupling of phenol and 4-chloropyridine and the Simmons-Smith cyclopropanation of styrene with ethyl diazoacetate. Volumetric microwave heating of the reactant fluids and local heating of CuZn/TiO2 catalyst could be established and resulted into an unprecedented continuous Cu-catalyzed liquid phase C-O coupling reaction with product yields up to 80%.
Original languageEnglish
Title of host publicationProceedings of the International Symposium on Chemical Reaction Engineering (ISCRE 22), 2-5 September 2012, Maastricht, the Nederlands
Place of PublicationMaastricht, the Nederlands
Publication statusPublished - 2012
Event22nd International Symposium on Chemical Reaction Engineering (ISCRE 22) - Maastricht, Netherlands
Duration: 2 Sep 20125 Sep 2012

Conference

Conference22nd International Symposium on Chemical Reaction Engineering (ISCRE 22)
Abbreviated titleISCRE 22
Country/TerritoryNetherlands
CityMaastricht
Period2/09/125/09/12

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