Probing exchange pathways in one-dimensional aggregates with super-resolution microscopy

L. Albertazzi, D. Zwaag, van der, C.M.A. Leenders, R.J. Fitzner, R.W. Hofstad, van der, E.W. Meijer

Research output: Contribution to journalArticleAcademicpeer-review

128 Citations (Scopus)
6 Downloads (Pure)


Supramolecular fibers are prominent structures in biology and chemistry. A quantitative understanding of molecular exchange pathways in these one-dimensional aggregates was obtained by a combination of super-resolution stochastic optical reconstruction microscopy and stochastic simulation. The potential of this methodology is demonstrated with a set of well-defined synthetic building blocks that self-assemble into supramolecular fibrils. Previous ensemble measurements hid all molecular phenomena underpinning monomer exchange, but the molecular pathway determined from single-aggregate studies revealed unexpected homogeneous exchange along the polymer backbone. These results pave the way for experimental investigation of the structure and exchange pathways of synthetic and natural supramolecular fibers.
Original languageEnglish
Pages (from-to)491-495
Issue number6183
Publication statusPublished - 2014

Fingerprint Dive into the research topics of 'Probing exchange pathways in one-dimensional aggregates with super-resolution microscopy'. Together they form a unique fingerprint.

  • Cite this