Pretargeting kit, method and agents used therein

Johan Lub; Wolter ten Hoeve; Raffaella Rossin; S.M. van den Bosch; Marc S. Robillard

Pretargeting kit, method and agents used therein

Johan Lub (Inventor)
, Wolter ten Hoeve (Inventor)
, Raffaella Rossin (Inventor)
, S.M. van den Bosch (Inventor)
, Marc S. Robillard (Inventor)

Research output: Patent › Patent publication

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Abstract

Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.

Original language	English
Patent number	US2013189184
IPC	A61K 51/ 10 A I
Priority date	11/10/11
Publication status	Published - 25 Jul 2013
Externally published	Yes

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title = "Pretargeting kit, method and agents used therein",

abstract = "Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.",

author = "Johan Lub and \{ten Hoeve\}, Wolter and Raffaella Rossin and \{van den Bosch\}, S.M. and Robillard, \{Marc S.\}",

year = "2013",

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day = "25",

language = "English",

type = "Patent",

note = "US2013189184; A61K 51/ 10 A I",

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TY - PAT

T1 - Pretargeting kit, method and agents used therein

AU - Lub, Johan

AU - ten Hoeve, Wolter

AU - Rossin, Raffaella

AU - van den Bosch, S.M.

AU - Robillard, Marc S.

PY - 2013/7/25

Y1 - 2013/7/25

N2 - Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.

AB - Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.

M3 - Patent publication

M1 - US2013189184

ER -

Pretargeting kit, method and agents used therein

Abstract

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