Pretargeting kit, method and agents used therein

Marc S. Robillard; Raffaella Rossin; Johan Lub; Pascal R. Verkerk; Dirk Burdinski

Pretargeting kit, method and agents used therein

Marc S. Robillard (Inventor), Raffaella Rossin (Inventor), Johan Lub (Inventor), Pascal R. Verkerk (Inventor), Dirk Burdinski (Inventor)

Research output: Patent › Patent publication

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Abstract

Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an alkene or alkyne dienohile.

Original language	English
Patent number	US2012039803
IPC	C07D 401/ 14 A I
Priority date	12/04/10
Publication status	Published - 16 Feb 2012
Externally published	Yes

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title = "Pretargeting kit, method and agents used therein",

abstract = "Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an alkene or alkyne dienohile.",

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T1 - Pretargeting kit, method and agents used therein

AU - Robillard, Marc S.

AU - Rossin, Raffaella

AU - Lub, Johan

AU - Verkerk, Pascal R.

AU - Burdinski, Dirk

PY - 2012/2/16

Y1 - 2012/2/16

N2 - Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an alkene or alkyne dienohile.

AB - Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an alkene or alkyne dienohile.

M3 - Patent publication

M1 - US2012039803

ER -

Pretargeting kit, method and agents used therein

Abstract

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