Pretargeting kit for imaging or therapy comprising a trans - cyclooctene dienophile and a diene

Marc Stefan Robillard (Inventor), Johan Lub (Inventor), Raffaella Rossin (Inventor), Sandra Martina van den Bosch (Inventor), Ronny Mathieu Versteegen (Inventor)

Research output: PatentPatent publication

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Abstract

Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels- Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has a flattened structure as a result of the position of at least two exocyclic bonds.

Original languageEnglish
Patent numberWO2012153254
IPCA61K 47/ 48 A I
Priority date9/05/11
Publication statusPublished - 15 Nov 2012

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