Pressure-dependence of arterial stiffness: potential clinical implications

B. Spronck, M.H.G. Heusinkveld, F.H. Vanmolkot, J. Roodt, Op 't, E. Hermeling, T. Delhaas, A.A. Kroon, K.D. Reesink

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Abstract

BACKGROUND:
Arterial stiffness measures such as pulse wave velocity (PWV) have a known dependence on actual blood pressure, requiring consideration in cardiovascular risk assessment and management. Given the impact of ageing on arterial wall structure, the pressure-dependence of PWV may vary with age.
METHODS:
Using a noninvasive model-based approach, combining carotid artery echo-tracking and tonometry waveforms, we obtained pressure-area curves in 23 hypertensive patients at baseline and after 3 months of antihypertensive treatment. We predicted the follow-up PWV decrease using modelled baseline curves and follow-up pressures. In addition, on the basis of these curves, we estimated PWV values for two age groups (mean ages 41 and 64 years) at predefined hypertensive (160/90 mmHg) and normotensive (120/80 mmHg) pressure ranges.
RESULTS:
Follow-up measurements showed a near 1 m/s decrease in carotid PWV when compared with baseline, which fully agreed with our model-prediction given the roughly 10 mmHg decrease in diastolic pressure. The stiffness-blood pressure-age pattern was in close agreement with corresponding data from the 'Reference Values for Arterial Stiffness' study, linking the physical and empirical bases of our findings.
CONCLUSION:
Our study demonstrates that the innate pressure-dependence of arterial stiffness may have implications for the clinical use of arterial stiffness measurements, both in risk assessment and in treatment monitoring of individual patients. We propose a number of clinically feasible approaches to account for the blood pressure effect on PWV measurements.
Original languageEnglish
Pages (from-to)330-338
JournalJournal of Hypertension
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 2015

Keywords

  • carotid artery
  • hypertension
  • pulse wave velocity
  • remodelling
  • ultrasonography

Cite this

Spronck, B. ; Heusinkveld, M.H.G. ; Vanmolkot, F.H. ; Roodt, Op 't, J. ; Hermeling, E. ; Delhaas, T. ; Kroon, A.A. ; Reesink, K.D. / Pressure-dependence of arterial stiffness : potential clinical implications. In: Journal of Hypertension. 2015 ; Vol. 33, No. 2. pp. 330-338.
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abstract = "BACKGROUND: Arterial stiffness measures such as pulse wave velocity (PWV) have a known dependence on actual blood pressure, requiring consideration in cardiovascular risk assessment and management. Given the impact of ageing on arterial wall structure, the pressure-dependence of PWV may vary with age.METHODS: Using a noninvasive model-based approach, combining carotid artery echo-tracking and tonometry waveforms, we obtained pressure-area curves in 23 hypertensive patients at baseline and after 3 months of antihypertensive treatment. We predicted the follow-up PWV decrease using modelled baseline curves and follow-up pressures. In addition, on the basis of these curves, we estimated PWV values for two age groups (mean ages 41 and 64 years) at predefined hypertensive (160/90 mmHg) and normotensive (120/80 mmHg) pressure ranges.RESULTS: Follow-up measurements showed a near 1 m/s decrease in carotid PWV when compared with baseline, which fully agreed with our model-prediction given the roughly 10 mmHg decrease in diastolic pressure. The stiffness-blood pressure-age pattern was in close agreement with corresponding data from the 'Reference Values for Arterial Stiffness' study, linking the physical and empirical bases of our findings.CONCLUSION: Our study demonstrates that the innate pressure-dependence of arterial stiffness may have implications for the clinical use of arterial stiffness measurements, both in risk assessment and in treatment monitoring of individual patients. We propose a number of clinically feasible approaches to account for the blood pressure effect on PWV measurements.",
keywords = "carotid artery, hypertension, pulse wave velocity, remodelling, ultrasonography",
author = "B. Spronck and M.H.G. Heusinkveld and F.H. Vanmolkot and {Roodt, Op 't}, J. and E. Hermeling and T. Delhaas and A.A. Kroon and K.D. Reesink",
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Spronck, B, Heusinkveld, MHG, Vanmolkot, FH, Roodt, Op 't, J, Hermeling, E, Delhaas, T, Kroon, AA & Reesink, KD 2015, 'Pressure-dependence of arterial stiffness: potential clinical implications', Journal of Hypertension, vol. 33, no. 2, pp. 330-338. https://doi.org/10.1097/HJH.0000000000000407

Pressure-dependence of arterial stiffness : potential clinical implications. / Spronck, B.; Heusinkveld, M.H.G.; Vanmolkot, F.H.; Roodt, Op 't, J.; Hermeling, E.; Delhaas, T.; Kroon, A.A.; Reesink, K.D.

In: Journal of Hypertension, Vol. 33, No. 2, 02.2015, p. 330-338.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Pressure-dependence of arterial stiffness

T2 - potential clinical implications

AU - Spronck, B.

AU - Heusinkveld, M.H.G.

AU - Vanmolkot, F.H.

AU - Roodt, Op 't, J.

AU - Hermeling, E.

AU - Delhaas, T.

AU - Kroon, A.A.

AU - Reesink, K.D.

PY - 2015/2

Y1 - 2015/2

N2 - BACKGROUND: Arterial stiffness measures such as pulse wave velocity (PWV) have a known dependence on actual blood pressure, requiring consideration in cardiovascular risk assessment and management. Given the impact of ageing on arterial wall structure, the pressure-dependence of PWV may vary with age.METHODS: Using a noninvasive model-based approach, combining carotid artery echo-tracking and tonometry waveforms, we obtained pressure-area curves in 23 hypertensive patients at baseline and after 3 months of antihypertensive treatment. We predicted the follow-up PWV decrease using modelled baseline curves and follow-up pressures. In addition, on the basis of these curves, we estimated PWV values for two age groups (mean ages 41 and 64 years) at predefined hypertensive (160/90 mmHg) and normotensive (120/80 mmHg) pressure ranges.RESULTS: Follow-up measurements showed a near 1 m/s decrease in carotid PWV when compared with baseline, which fully agreed with our model-prediction given the roughly 10 mmHg decrease in diastolic pressure. The stiffness-blood pressure-age pattern was in close agreement with corresponding data from the 'Reference Values for Arterial Stiffness' study, linking the physical and empirical bases of our findings.CONCLUSION: Our study demonstrates that the innate pressure-dependence of arterial stiffness may have implications for the clinical use of arterial stiffness measurements, both in risk assessment and in treatment monitoring of individual patients. We propose a number of clinically feasible approaches to account for the blood pressure effect on PWV measurements.

AB - BACKGROUND: Arterial stiffness measures such as pulse wave velocity (PWV) have a known dependence on actual blood pressure, requiring consideration in cardiovascular risk assessment and management. Given the impact of ageing on arterial wall structure, the pressure-dependence of PWV may vary with age.METHODS: Using a noninvasive model-based approach, combining carotid artery echo-tracking and tonometry waveforms, we obtained pressure-area curves in 23 hypertensive patients at baseline and after 3 months of antihypertensive treatment. We predicted the follow-up PWV decrease using modelled baseline curves and follow-up pressures. In addition, on the basis of these curves, we estimated PWV values for two age groups (mean ages 41 and 64 years) at predefined hypertensive (160/90 mmHg) and normotensive (120/80 mmHg) pressure ranges.RESULTS: Follow-up measurements showed a near 1 m/s decrease in carotid PWV when compared with baseline, which fully agreed with our model-prediction given the roughly 10 mmHg decrease in diastolic pressure. The stiffness-blood pressure-age pattern was in close agreement with corresponding data from the 'Reference Values for Arterial Stiffness' study, linking the physical and empirical bases of our findings.CONCLUSION: Our study demonstrates that the innate pressure-dependence of arterial stiffness may have implications for the clinical use of arterial stiffness measurements, both in risk assessment and in treatment monitoring of individual patients. We propose a number of clinically feasible approaches to account for the blood pressure effect on PWV measurements.

KW - carotid artery

KW - hypertension

KW - pulse wave velocity

KW - remodelling

KW - ultrasonography

U2 - 10.1097/HJH.0000000000000407

DO - 10.1097/HJH.0000000000000407

M3 - Article

C2 - 25380150

VL - 33

SP - 330

EP - 338

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 2

ER -

Spronck B, Heusinkveld MHG, Vanmolkot FH, Roodt, Op 't J, Hermeling E, Delhaas T et al. Pressure-dependence of arterial stiffness: potential clinical implications. Journal of Hypertension. 2015 Feb;33(2):330-338. https://doi.org/10.1097/HJH.0000000000000407