Preparation of stable dispersion of barium titanate nanoparticles: potential applications in biomedicine

G. Ciofani, S. Danti, S. Moscato, L. Albertazzi, D. D'Alessandro, D. Dinucci, F. Chiellini, M. Petrini, A. Menciassi

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Abstract

Nanoscale structures and materials have been explored in many biological applications because of their extraordinary novel properties. Here we propose a study of cellular interactions with barium titanate nanoparticles, an interesting ceramic material that has received a lot of interest in the nanotechnology research, but without any attention about its biological potential. We introduced for the first time an efficient method for the preparation of stable aqueous dispersions of barium titanate nanoparticles, characterized with FIB, TEM and AFM imaging, light scattering, Z-potential and UV/vis analysis. Finally, we presented a systematic study of short-term cytotoxicity of the prepared dispersion based both on quantitative (metabolism, proliferation) and qualitative (apoptosis, viability, differentiation) assays.

Original languageEnglish
Pages (from-to)535-543
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume76
Issue number2
DOIs
Publication statusPublished - 1 Apr 2010
Externally publishedYes

Keywords

  • Barium titanate nanoparticles
  • Cellular up-take
  • Cytocompatibility
  • H9C2 cells

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