Preparation and antimycotic properties of derivatives of 1-phenethylimidazole

E.F. Godefroi, J. Heeres, J. Cutsem, van, P.A.J. Janssen

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The synthesis of a large no. of b-substituted-1-phenethylimidazoles is described. Many appropriately N-substituted-1-(b-aminophenethyl)imidazoles and cyclic ketals derived from 2-(1-imidazolyl)acetophenones were quite active against dermatophytes. However, 1-(b-benzyloxyphenethyl)-imidazoles displayed potent, broad-spectrum activity, not only against dermatophytes but also against yeast cells (Candida albicans) and gram-pos. bacteria.
Original languageEnglish
Pages (from-to)784-791
Number of pages8
JournalJournal of Medicinal Chemistry
Issue number5
Publication statusPublished - 1969


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