Preparation and antimycotic properties of derivatives of 1-phenethylimidazole

E.F. Godefroi; J. Heeres; J. Cutsem, van; P.A.J. Janssen

doi:10.1021/jm00305a014

Preparation and antimycotic properties of derivatives of 1-phenethylimidazole

E.F. Godefroi, J. Heeres, J. Cutsem, van, P.A.J. Janssen

Department of Chemical Engineering and Chemistry

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The synthesis of a large no. of b-substituted-1-phenethylimidazoles is described. Many appropriately N-substituted-1-(b-aminophenethyl)imidazoles and cyclic ketals derived from 2-(1-imidazolyl)acetophenones were quite active against dermatophytes. However, 1-(b-benzyloxyphenethyl)-imidazoles displayed potent, broad-spectrum activity, not only against dermatophytes but also against yeast cells (Candida albicans) and gram-pos. bacteria.

Original language	English
Pages (from-to)	784-791
Number of pages	8
Journal	Journal of Medicinal Chemistry
Volume	12
Issue number	5
DOIs	https://doi.org/10.1021/jm00305a014
Publication status	Published - 1969

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title = "Preparation and antimycotic properties of derivatives of 1-phenethylimidazole",

abstract = "The synthesis of a large no. of b-substituted-1-phenethylimidazoles is described. Many appropriately N-substituted-1-(b-aminophenethyl)imidazoles and cyclic ketals derived from 2-(1-imidazolyl)acetophenones were quite active against dermatophytes. However, 1-(b-benzyloxyphenethyl)-imidazoles displayed potent, broad-spectrum activity, not only against dermatophytes but also against yeast cells (Candida albicans) and gram-pos. bacteria.",

author = "E.F. Godefroi and J. Heeres and {Cutsem, van}, J. and P.A.J. Janssen",

year = "1969",

doi = "10.1021/jm00305a014",

language = "English",

volume = "12",

pages = "784--791",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

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T1 - Preparation and antimycotic properties of derivatives of 1-phenethylimidazole

AU - Godefroi, E.F.

AU - Heeres, J.

AU - Cutsem, van, J.

AU - Janssen, P.A.J.

PY - 1969

Y1 - 1969

N2 - The synthesis of a large no. of b-substituted-1-phenethylimidazoles is described. Many appropriately N-substituted-1-(b-aminophenethyl)imidazoles and cyclic ketals derived from 2-(1-imidazolyl)acetophenones were quite active against dermatophytes. However, 1-(b-benzyloxyphenethyl)-imidazoles displayed potent, broad-spectrum activity, not only against dermatophytes but also against yeast cells (Candida albicans) and gram-pos. bacteria.

AB - The synthesis of a large no. of b-substituted-1-phenethylimidazoles is described. Many appropriately N-substituted-1-(b-aminophenethyl)imidazoles and cyclic ketals derived from 2-(1-imidazolyl)acetophenones were quite active against dermatophytes. However, 1-(b-benzyloxyphenethyl)-imidazoles displayed potent, broad-spectrum activity, not only against dermatophytes but also against yeast cells (Candida albicans) and gram-pos. bacteria.

U2 - 10.1021/jm00305a014

DO - 10.1021/jm00305a014

M3 - Article

VL - 12

SP - 784

EP - 791

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 5

ER -