Abstract
The synthesis of a large no. of b-substituted-1-phenethylimidazoles is described. Many appropriately N-substituted-1-(b-aminophenethyl)imidazoles and cyclic ketals derived from 2-(1-imidazolyl)acetophenones were quite active against dermatophytes. However, 1-(b-benzyloxyphenethyl)-imidazoles displayed potent, broad-spectrum activity, not only against dermatophytes but also against yeast cells (Candida albicans) and gram-pos. bacteria.
Original language | English |
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Pages (from-to) | 784-791 |
Number of pages | 8 |
Journal | Journal of Medicinal Chemistry |
Volume | 12 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1969 |