Prediction of murine liver kinetics from plasma lipoprotein distributions

C.A. Tiemann, S.A.A. Berg, van den, J.B. Klinken, van, K.W. Dijk, van, J.A.L. Jeneson, P.A.J. Hilbers, N.A.W. Riel, van

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

The role of liver in lipid metabolism has been studied extensively. However, due to the complexity of in vivo liver measurements, many experimental efforts have focused on studying liver responses by measuring plasma lipoprotein distributions. The characteristics of these distributions co-determine several metabolic disease risks and depend on production, clearance and remodeling of lipoproteins, all regulated by the liver. A challenge remains to determine the kinetics and distribution of fluxes in the complex network of metabolic pathways in the liver that give rise to these distributions. Here, we report on a computational approach to obtain this information. A computational multi-compartment model was constructed including reactions representing lipogenesis, cholesterol synthesis, fatty acid handling and lipoprotein metabolism in liver and lipoprotein remodeling in plasma. We consider a high-resolution grid of different lipoprotein classes, from which lipoprotein distributions are calculated. Novel in this approach is the inclusion of lipoprotein kinetics, yielding additional information to constrain internal liver predictions and vice versa. In future, the model will be used to study the dynamic interactive behavior of plasma lipoprotein metabolism and metabolic pathways in murine liver for different physiological conditions.
LanguageEnglish
Title of host publicationProceedings of the Experimental Biology 2010, 24-28 April 2010, Anaheim, California, USA
StatePublished - 2010

Fingerprint

lipoproteins
liver
kinetics
predictions
metabolism
metabolic diseases
lipid metabolism
cholesterol
clearances
compartments
fatty acids
grids
inclusions
high resolution

Cite this

Tiemann, C. A., Berg, van den, S. A. A., Klinken, van, J. B., Dijk, van, K. W., Jeneson, J. A. L., Hilbers, P. A. J., & Riel, van, N. A. W. (2010). Prediction of murine liver kinetics from plasma lipoprotein distributions. In Proceedings of the Experimental Biology 2010, 24-28 April 2010, Anaheim, California, USA
Tiemann, C.A. ; Berg, van den, S.A.A. ; Klinken, van, J.B. ; Dijk, van, K.W. ; Jeneson, J.A.L. ; Hilbers, P.A.J. ; Riel, van, N.A.W./ Prediction of murine liver kinetics from plasma lipoprotein distributions. Proceedings of the Experimental Biology 2010, 24-28 April 2010, Anaheim, California, USA. 2010.
@inproceedings{f54a3e8d362346e08a628292c3ca14b4,
title = "Prediction of murine liver kinetics from plasma lipoprotein distributions",
abstract = "The role of liver in lipid metabolism has been studied extensively. However, due to the complexity of in vivo liver measurements, many experimental efforts have focused on studying liver responses by measuring plasma lipoprotein distributions. The characteristics of these distributions co-determine several metabolic disease risks and depend on production, clearance and remodeling of lipoproteins, all regulated by the liver. A challenge remains to determine the kinetics and distribution of fluxes in the complex network of metabolic pathways in the liver that give rise to these distributions. Here, we report on a computational approach to obtain this information. A computational multi-compartment model was constructed including reactions representing lipogenesis, cholesterol synthesis, fatty acid handling and lipoprotein metabolism in liver and lipoprotein remodeling in plasma. We consider a high-resolution grid of different lipoprotein classes, from which lipoprotein distributions are calculated. Novel in this approach is the inclusion of lipoprotein kinetics, yielding additional information to constrain internal liver predictions and vice versa. In future, the model will be used to study the dynamic interactive behavior of plasma lipoprotein metabolism and metabolic pathways in murine liver for different physiological conditions.",
author = "C.A. Tiemann and {Berg, van den}, S.A.A. and {Klinken, van}, J.B. and {Dijk, van}, K.W. and J.A.L. Jeneson and P.A.J. Hilbers and {Riel, van}, N.A.W.",
year = "2010",
language = "English",
booktitle = "Proceedings of the Experimental Biology 2010, 24-28 April 2010, Anaheim, California, USA",

}

Tiemann, CA, Berg, van den, SAA, Klinken, van, JB, Dijk, van, KW, Jeneson, JAL, Hilbers, PAJ & Riel, van, NAW 2010, Prediction of murine liver kinetics from plasma lipoprotein distributions. in Proceedings of the Experimental Biology 2010, 24-28 April 2010, Anaheim, California, USA.

Prediction of murine liver kinetics from plasma lipoprotein distributions. / Tiemann, C.A.; Berg, van den, S.A.A.; Klinken, van, J.B.; Dijk, van, K.W.; Jeneson, J.A.L.; Hilbers, P.A.J.; Riel, van, N.A.W.

Proceedings of the Experimental Biology 2010, 24-28 April 2010, Anaheim, California, USA. 2010.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - Prediction of murine liver kinetics from plasma lipoprotein distributions

AU - Tiemann,C.A.

AU - Berg, van den,S.A.A.

AU - Klinken, van,J.B.

AU - Dijk, van,K.W.

AU - Jeneson,J.A.L.

AU - Hilbers,P.A.J.

AU - Riel, van,N.A.W.

PY - 2010

Y1 - 2010

N2 - The role of liver in lipid metabolism has been studied extensively. However, due to the complexity of in vivo liver measurements, many experimental efforts have focused on studying liver responses by measuring plasma lipoprotein distributions. The characteristics of these distributions co-determine several metabolic disease risks and depend on production, clearance and remodeling of lipoproteins, all regulated by the liver. A challenge remains to determine the kinetics and distribution of fluxes in the complex network of metabolic pathways in the liver that give rise to these distributions. Here, we report on a computational approach to obtain this information. A computational multi-compartment model was constructed including reactions representing lipogenesis, cholesterol synthesis, fatty acid handling and lipoprotein metabolism in liver and lipoprotein remodeling in plasma. We consider a high-resolution grid of different lipoprotein classes, from which lipoprotein distributions are calculated. Novel in this approach is the inclusion of lipoprotein kinetics, yielding additional information to constrain internal liver predictions and vice versa. In future, the model will be used to study the dynamic interactive behavior of plasma lipoprotein metabolism and metabolic pathways in murine liver for different physiological conditions.

AB - The role of liver in lipid metabolism has been studied extensively. However, due to the complexity of in vivo liver measurements, many experimental efforts have focused on studying liver responses by measuring plasma lipoprotein distributions. The characteristics of these distributions co-determine several metabolic disease risks and depend on production, clearance and remodeling of lipoproteins, all regulated by the liver. A challenge remains to determine the kinetics and distribution of fluxes in the complex network of metabolic pathways in the liver that give rise to these distributions. Here, we report on a computational approach to obtain this information. A computational multi-compartment model was constructed including reactions representing lipogenesis, cholesterol synthesis, fatty acid handling and lipoprotein metabolism in liver and lipoprotein remodeling in plasma. We consider a high-resolution grid of different lipoprotein classes, from which lipoprotein distributions are calculated. Novel in this approach is the inclusion of lipoprotein kinetics, yielding additional information to constrain internal liver predictions and vice versa. In future, the model will be used to study the dynamic interactive behavior of plasma lipoprotein metabolism and metabolic pathways in murine liver for different physiological conditions.

M3 - Conference contribution

BT - Proceedings of the Experimental Biology 2010, 24-28 April 2010, Anaheim, California, USA

ER -

Tiemann CA, Berg, van den SAA, Klinken, van JB, Dijk, van KW, Jeneson JAL, Hilbers PAJ et al. Prediction of murine liver kinetics from plasma lipoprotein distributions. In Proceedings of the Experimental Biology 2010, 24-28 April 2010, Anaheim, California, USA. 2010.