Prediction of Late-Onset Sepsis in Preterm Infants Using Monitoring Signals and Machine Learning

Laura Cabrera-Quiros, Deedee Kommers (Corresponding author), Maria K Wolvers, Laurien Oosterwijk, Niek Arents, Jacqueline van der Sluijs-Bens, Eduardus J E Cottaar, Peter Andriessen, Carola van Pul

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objectives: Prediction of late-onset sepsis (onset beyond day 3 of life) in preterm infants, based on multiple patient monitoring signals 24 hours before onset.

Design: Continuous high-resolution electrocardiogram and respiration (chest impedance) data from the monitoring signals were extracted and used to create time-interval features representing heart rate variability, respiration, and body motion. For each infant with a blood culture-proven late-onset sepsis, a Cultures, Resuscitation, and Antibiotics Started Here moment was defined. The Cultures, Resuscitation, and Antibiotics Started Here moment served as an anchor point for the prediction analysis. In the group with controls (C), an "equivalent crash moment" was calculated as anchor point, based on comparable gestational and postnatal age. Three common machine learning approaches (logistic regressor, naive Bayes, and nearest mean classifier) were used to binary classify samples of late-onset sepsis from C. For training and evaluation of the three classifiers, a leave-k-subjects-out cross-validation was used.

Setting: Level III neonatal ICU.

Patients: The patient population consisted of 32 premature infants with sepsis and 32 age-matched control patients.

Interventions: No interventions were performed.

Measurements and Main Results: For the interval features representing heart rate variability, respiration, and body motion, differences between late-onset sepsis and C were visible up to 5 hours preceding the Cultures, Resuscitation, and Antibiotics Started Here moment. Using a combination of all features, classification of late-onset sepsis and C showed a mean accuracy of 0.79 ± 0.12 and mean precision rate of 0.82 ± 0.18 3 hours before the onset of sepsis.

Conclusions: Information from routine patient monitoring can be used to predict sepsis. Specifically, this study shows that a combination of electrocardiogram-based, respiration-based, and motion-based features enables the prediction of late-onset sepsis hours before the clinical crash moment.

Original languageEnglish
Article numbere0302
Number of pages10
JournalCritical Care Explorations
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 2021

Bibliographical note

Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

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