Prediction-based delay compensation for staged crystallization

Research output: Contribution to conferenceAbstractAcademic

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Abstract

Traditionally, the crystallization of active pharmaceutical ingredients (API) and other chemical specialities has been operated in batch or semi-batch mode under strictly regulated recipes. However, batch operations have disadvantages such as lack of batch to batch reproducibility, long processing times, scale up issues, poor controllability and observability. Continuous operation can overcome these drawbacks, although a higher degree of automation and a more in depth process understanding is required for successful continuous API production. Therefore, recent research efforts are directed towards the design of continuous crystallization processes. Multistage mixed suspension mixed product removal (MSMPR) crystallization might be the most convenient route of transition from batch to continuous operation, since current crystallizers in industry are of the stirred tank type. Majority of the work in this area has studied the steady state properties of these systems whereas only a few works deal with the process dynamics and control of these units.
In this work, an advanced control scheme for average crystal dimension control in industrial-scale two stage MSMPR crystallizers is proposed and tested in simulation.
Original languageEnglish
Pages155
Publication statusPublished - 2018
Event37th Benelux Meeting on Systems and Control - Kontakt der Kontinenten, Soesterberg, Netherlands
Duration: 27 Mar 201829 Mar 2018
http://www.beneluxmeeting.nl/2018/

Conference

Conference37th Benelux Meeting on Systems and Control
CountryNetherlands
CitySoesterberg
Period27/03/1829/03/18
Internet address

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Crystallizers
Crystallization
Drug products
Observability
Controllability
Automation
Crystals
Processing
Compensation and Redress
Industry

Cite this

Porru, M., & Ozkan, L. (2018). Prediction-based delay compensation for staged crystallization. 155. Abstract from 37th Benelux Meeting on Systems and Control, Soesterberg, Netherlands.
Porru, M. ; Ozkan, L. / Prediction-based delay compensation for staged crystallization. Abstract from 37th Benelux Meeting on Systems and Control, Soesterberg, Netherlands.
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Porru, M & Ozkan, L 2018, 'Prediction-based delay compensation for staged crystallization' 37th Benelux Meeting on Systems and Control, Soesterberg, Netherlands, 27/03/18 - 29/03/18, pp. 155.

Prediction-based delay compensation for staged crystallization. / Porru, M.; Ozkan, L.

2018. 155 Abstract from 37th Benelux Meeting on Systems and Control, Soesterberg, Netherlands.

Research output: Contribution to conferenceAbstractAcademic

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AB - Traditionally, the crystallization of active pharmaceutical ingredients (API) and other chemical specialities has been operated in batch or semi-batch mode under strictly regulated recipes. However, batch operations have disadvantages such as lack of batch to batch reproducibility, long processing times, scale up issues, poor controllability and observability. Continuous operation can overcome these drawbacks, although a higher degree of automation and a more in depth process understanding is required for successful continuous API production. Therefore, recent research efforts are directed towards the design of continuous crystallization processes. Multistage mixed suspension mixed product removal (MSMPR) crystallization might be the most convenient route of transition from batch to continuous operation, since current crystallizers in industry are of the stirred tank type. Majority of the work in this area has studied the steady state properties of these systems whereas only a few works deal with the process dynamics and control of these units.In this work, an advanced control scheme for average crystal dimension control in industrial-scale two stage MSMPR crystallizers is proposed and tested in simulation.

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Porru M, Ozkan L. Prediction-based delay compensation for staged crystallization. 2018. Abstract from 37th Benelux Meeting on Systems and Control, Soesterberg, Netherlands.