Polynitroxyl functionalized dendrimers as paramagnetic relaxation enhancers : effects of structure on relaxivity

A.J. Maliakal, N.J. Turro, A.W. Bosman, J. Cornel, E.W. Meijer

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

Abstract

The 1H NMR relaxivity of ortho and para dinitroxide substituted phthalate esters and a series of nitroxyl functionalized poly(propylene imine) dendrimers has been measured in acetonitrile and methanol. Studies of dinitroxide relaxivity indicate that electron exchange rate has only a small effect on relaxivity. In studies on dendritic polynitroxides, the per-nitroxide based relaxivity nearly doubles for the generation 5 nitroxyl functionalized dendrimer as compared to a mononitroxide model. This relaxivity enhancement may be due to crowding of dendrimer surface groups in higher generation dendrimers. Dendritic polynitroxides exhibit high relaxivities, making them exciting candidates for magnetic resonance imaging applications. [on SciFinder (R)]
Original languageEnglish
Title of host publicationAbstracts of Papers, 226th ACS National Meeting, New York, NY, United States, September 7-11, 2003
Place of PublicationWashington
PublisherAmerican Chemical Society
PagesORGN-353
ISBN (Print)0-8412-3889-8
Publication statusPublished - 2003
Event226th ACS National Meeting - New York, United States
Duration: 7 Sep 200311 Sep 2003

Conference

Conference226th ACS National Meeting
CountryUnited States
CityNew York
Period7/09/0311/09/03

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