Polynitroxyl functionalized dendrimers as paramagnetic relaxation enhancers : effects of structure on relaxivity

A.J. Maliakal; N.J. Turro; A.W. Bosman; J. Cornel; E.W. Meijer

Polynitroxyl functionalized dendrimers as paramagnetic relaxation enhancers : effects of structure on relaxivity

A.J. Maliakal, N.J. Turro, A.W. Bosman, J. Cornel, E.W. Meijer

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

Abstract

The 1H NMR relaxivity of ortho and para dinitroxide substituted phthalate esters and a series of nitroxyl functionalized poly(propylene imine) dendrimers has been measured in acetonitrile and methanol. Studies of dinitroxide relaxivity indicate that electron exchange rate has only a small effect on relaxivity. In studies on dendritic polynitroxides, the per-nitroxide based relaxivity nearly doubles for the generation 5 nitroxyl functionalized dendrimer as compared to a mononitroxide model. This relaxivity enhancement may be due to crowding of dendrimer surface groups in higher generation dendrimers. Dendritic polynitroxides exhibit high relaxivities, making them exciting candidates for magnetic resonance imaging applications. [on SciFinder (R)]

Original language	English
Title of host publication	Abstracts of Papers, 226th ACS National Meeting, New York, NY, United States, September 7-11, 2003
Place of Publication	Washington
Publisher	American Chemical Society
Pages	ORGN-353
ISBN (Print)	0-8412-3889-8
Publication status	Published - 2003
Event	226th ACS National Meeting - New York, United States Duration: 7 Sept 2003 → 11 Sept 2003

Conference

Conference	226th ACS National Meeting
Country/Territory	United States
City	New York
Period	7/09/03 → 11/09/03

Cite this

@inproceedings{0077447a6621490d93b8cdb4b4064aef,

title = "Polynitroxyl functionalized dendrimers as paramagnetic relaxation enhancers : effects of structure on relaxivity",

abstract = "The 1H NMR relaxivity of ortho and para dinitroxide substituted phthalate esters and a series of nitroxyl functionalized poly(propylene imine) dendrimers has been measured in acetonitrile and methanol. Studies of dinitroxide relaxivity indicate that electron exchange rate has only a small effect on relaxivity. In studies on dendritic polynitroxides, the per-nitroxide based relaxivity nearly doubles for the generation 5 nitroxyl functionalized dendrimer as compared to a mononitroxide model. This relaxivity enhancement may be due to crowding of dendrimer surface groups in higher generation dendrimers. Dendritic polynitroxides exhibit high relaxivities, making them exciting candidates for magnetic resonance imaging applications. [on SciFinder (R)]",

author = "A.J. Maliakal and N.J. Turro and A.W. Bosman and J. Cornel and E.W. Meijer",

year = "2003",

language = "English",

isbn = "0-8412-3889-8",

pages = "ORGN--353",

booktitle = "Abstracts of Papers, 226th ACS National Meeting, New York, NY, United States, September 7-11, 2003",

publisher = "American Chemical Society",

address = "United States",

note = "226th ACS National Meeting ; Conference date: 07-09-2003 Through 11-09-2003",

}

Maliakal, AJ, Turro, NJ, Bosman, AW, Cornel, J & Meijer, EW 2003, Polynitroxyl functionalized dendrimers as paramagnetic relaxation enhancers : effects of structure on relaxivity. in Abstracts of Papers, 226th ACS National Meeting, New York, NY, United States, September 7-11, 2003. American Chemical Society, Washington, pp. ORGN-353, 226th ACS National Meeting, New York, New York, United States, 7/09/03.

Polynitroxyl functionalized dendrimers as paramagnetic relaxation enhancers : effects of structure on relaxivity. / Maliakal, A.J.; Turro, N.J.; Bosman, A.W. et al.
Abstracts of Papers, 226th ACS National Meeting, New York, NY, United States, September 7-11, 2003. Washington: American Chemical Society, 2003. p. ORGN-353.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

TY - GEN

T1 - Polynitroxyl functionalized dendrimers as paramagnetic relaxation enhancers : effects of structure on relaxivity

AU - Maliakal, A.J.

AU - Turro, N.J.

AU - Bosman, A.W.

AU - Cornel, J.

AU - Meijer, E.W.

PY - 2003

Y1 - 2003

N2 - The 1H NMR relaxivity of ortho and para dinitroxide substituted phthalate esters and a series of nitroxyl functionalized poly(propylene imine) dendrimers has been measured in acetonitrile and methanol. Studies of dinitroxide relaxivity indicate that electron exchange rate has only a small effect on relaxivity. In studies on dendritic polynitroxides, the per-nitroxide based relaxivity nearly doubles for the generation 5 nitroxyl functionalized dendrimer as compared to a mononitroxide model. This relaxivity enhancement may be due to crowding of dendrimer surface groups in higher generation dendrimers. Dendritic polynitroxides exhibit high relaxivities, making them exciting candidates for magnetic resonance imaging applications. [on SciFinder (R)]

AB - The 1H NMR relaxivity of ortho and para dinitroxide substituted phthalate esters and a series of nitroxyl functionalized poly(propylene imine) dendrimers has been measured in acetonitrile and methanol. Studies of dinitroxide relaxivity indicate that electron exchange rate has only a small effect on relaxivity. In studies on dendritic polynitroxides, the per-nitroxide based relaxivity nearly doubles for the generation 5 nitroxyl functionalized dendrimer as compared to a mononitroxide model. This relaxivity enhancement may be due to crowding of dendrimer surface groups in higher generation dendrimers. Dendritic polynitroxides exhibit high relaxivities, making them exciting candidates for magnetic resonance imaging applications. [on SciFinder (R)]

M3 - Conference contribution

SN - 0-8412-3889-8

SP - ORGN-353

BT - Abstracts of Papers, 226th ACS National Meeting, New York, NY, United States, September 7-11, 2003

PB - American Chemical Society

CY - Washington

T2 - 226th ACS National Meeting

Y2 - 7 September 2003 through 11 September 2003

ER -

Polynitroxyl functionalized dendrimers as paramagnetic relaxation enhancers : effects of structure on relaxivity

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