Polymersomes as a potential platform for cancer immunotherapy

J.F. Scheerstra; A.C. Wauters; J. Tel; L.K.E.A. Abdelmohsen; J.C.M. van Hest

doi:10.1016/j.mtadv.2021.100203

Polymersomes as a potential platform for cancer immunotherapy

J.F. Scheerstra, A.C. Wauters, J. Tel, L.K.E.A. Abdelmohsen (Corresponding author), J.C.M. van Hest (Corresponding author)

Research output: Contribution to journal › Review article › peer-review

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Abstract

With the focus in the field of cancer nanomedicine shifting from direct tumor targeting to modulation of the immune system, new opportunities arise for the employment of nanocarrier systems. Polymeric nanovesicles, or polymersomes, have been under investigation as a potential nanocarrier platform for the past decades. These investigations have enhanced our fundamental knowledge on how to tailor physicochemical properties, such as size and shape, surface chemistry and functionalization, and membrane characteristics. The versatile nature and high structural stability of polymersomes makes them suitable for cancer treatment that goes beyond drug delivery. Rational nanocarrier design allows for the spatiotemporal control over the function of specific immune cell targets to enhance cancer immunotherapy. This review provides a perspective view on the potential of polymersomes as a multifunctional platform for in vivo cancer immunotherapy. We discuss opportunities to implement polymersomes in the field, elaborate on their design considerations for immunotherapeutic applications and compare polymersomes with lipid nanoparticles and other relevant systems. Current challenges and future perspectives are addressed to underline what is needed to employ polymersomes as a platform for cancer immunotherapy.

Original language	English
Article number	100203
Number of pages	13
Journal	Materials Today Advances
Volume	13
DOIs	https://doi.org/10.1016/j.mtadv.2021.100203
Publication status	Published - Mar 2022

Bibliographical note

Funding Information:
A.C.W, L.K.E.A.A, and J.C.M.v.H acknowledge support from the Dutch Ministry of Education, Culture and Science (Gravitation Program 024.001.035 ) and the ERC Advanced Grant (Artisym 694120 ). J.C.M.v.H and J.F.S. also acknowledge support by the Spinoza premium. Schematic illustrations of mice, monkey and cells were created with BioRender.com .

Funding

A.C.W, L.K.E.A.A, and J.C.M.v.H acknowledge support from the Dutch Ministry of Education, Culture and Science (Gravitation Program 024.001.035 ) and the ERC Advanced Grant (Artisym 694120 ). J.C.M.v.H and J.F.S. also acknowledge support by the Spinoza premium. Schematic illustrations of mice, monkey and cells were created with BioRender.com .

Keywords

Cancer immunotherapy
Immunomodulation
Nanomedicine
Physicochemical properties
Polymersomes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mtadv.2021.100203

published versionFinal published version, 1.97 MBLicence: CC BY

Cite this

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abstract = "With the focus in the field of cancer nanomedicine shifting from direct tumor targeting to modulation of the immune system, new opportunities arise for the employment of nanocarrier systems. Polymeric nanovesicles, or polymersomes, have been under investigation as a potential nanocarrier platform for the past decades. These investigations have enhanced our fundamental knowledge on how to tailor physicochemical properties, such as size and shape, surface chemistry and functionalization, and membrane characteristics. The versatile nature and high structural stability of polymersomes makes them suitable for cancer treatment that goes beyond drug delivery. Rational nanocarrier design allows for the spatiotemporal control over the function of specific immune cell targets to enhance cancer immunotherapy. This review provides a perspective view on the potential of polymersomes as a multifunctional platform for in vivo cancer immunotherapy. We discuss opportunities to implement polymersomes in the field, elaborate on their design considerations for immunotherapeutic applications and compare polymersomes with lipid nanoparticles and other relevant systems. Current challenges and future perspectives are addressed to underline what is needed to employ polymersomes as a platform for cancer immunotherapy.",

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AU - van Hest, J.C.M.

N1 - Funding Information: A.C.W, L.K.E.A.A, and J.C.M.v.H acknowledge support from the Dutch Ministry of Education, Culture and Science (Gravitation Program 024.001.035 ) and the ERC Advanced Grant (Artisym 694120 ). J.C.M.v.H and J.F.S. also acknowledge support by the Spinoza premium. Schematic illustrations of mice, monkey and cells were created with BioRender.com .

PY - 2022/3

Y1 - 2022/3

N2 - With the focus in the field of cancer nanomedicine shifting from direct tumor targeting to modulation of the immune system, new opportunities arise for the employment of nanocarrier systems. Polymeric nanovesicles, or polymersomes, have been under investigation as a potential nanocarrier platform for the past decades. These investigations have enhanced our fundamental knowledge on how to tailor physicochemical properties, such as size and shape, surface chemistry and functionalization, and membrane characteristics. The versatile nature and high structural stability of polymersomes makes them suitable for cancer treatment that goes beyond drug delivery. Rational nanocarrier design allows for the spatiotemporal control over the function of specific immune cell targets to enhance cancer immunotherapy. This review provides a perspective view on the potential of polymersomes as a multifunctional platform for in vivo cancer immunotherapy. We discuss opportunities to implement polymersomes in the field, elaborate on their design considerations for immunotherapeutic applications and compare polymersomes with lipid nanoparticles and other relevant systems. Current challenges and future perspectives are addressed to underline what is needed to employ polymersomes as a platform for cancer immunotherapy.

AB - With the focus in the field of cancer nanomedicine shifting from direct tumor targeting to modulation of the immune system, new opportunities arise for the employment of nanocarrier systems. Polymeric nanovesicles, or polymersomes, have been under investigation as a potential nanocarrier platform for the past decades. These investigations have enhanced our fundamental knowledge on how to tailor physicochemical properties, such as size and shape, surface chemistry and functionalization, and membrane characteristics. The versatile nature and high structural stability of polymersomes makes them suitable for cancer treatment that goes beyond drug delivery. Rational nanocarrier design allows for the spatiotemporal control over the function of specific immune cell targets to enhance cancer immunotherapy. This review provides a perspective view on the potential of polymersomes as a multifunctional platform for in vivo cancer immunotherapy. We discuss opportunities to implement polymersomes in the field, elaborate on their design considerations for immunotherapeutic applications and compare polymersomes with lipid nanoparticles and other relevant systems. Current challenges and future perspectives are addressed to underline what is needed to employ polymersomes as a platform for cancer immunotherapy.

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Polymersomes as a potential platform for cancer immunotherapy

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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