Polymersome nanoreactors for enzymatic ring-opening polymerization

M. Nallani, H.P.M. de Hoog, J.J.L.M. Cornelissen, A.R.A. Palmans, J.C.M. van Hest, R.J.M. Nolte

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Abstract

Polystyrene-polyisocyanopeptide (PS-PIAT) polymersomes containing CALB in two different locations, one in the aqueous inner compartment and one in the bilayer, were investigated for enzymatic ring-opening polymerization of lactones in water. It is shown that the monomers 8-octanolactone and dodecalactone yield oligomers with this polymersome system. It is also observed that the polymerization activity is dependent on the position of the enzyme in the polymersome. SEM investigations show that the polymersome structures were destabilized during the polymerization. Further investigations show that the vesicular morphology of the polymersomes was destabilized only in the case of polymer product formation.

Original languageEnglish
Pages (from-to)3723-3728
Number of pages6
JournalBiomacromolecules
Volume8
Issue number12
DOIs
Publication statusPublished - Dec 2007

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    Nallani, M., de Hoog, H. P. M., Cornelissen, J. J. L. M., Palmans, A. R. A., van Hest, J. C. M., & Nolte, R. J. M. (2007). Polymersome nanoreactors for enzymatic ring-opening polymerization. Biomacromolecules, 8(12), 3723-3728. https://doi.org/10.1021/bm7005938