Polymeric nanocontainers with high loading capacity of hydrophobic drugs

O.G. Schramm, M.A.R. Meier, R. Hoogenboom, H.H.P Erp, van, J.M.W. Gohy, U.S. Schubert

Research output: Contribution to journalArticleAcademicpeer-review

38 Citations (Scopus)

Abstract

Water sol. 4- and 6-arm star-shaped polymers with (bio)degradable hydrophobic cores and dense hydrophilic coronas were synthesized by a combination of ring opening polymn. (ROP) and atom transfer radical polymn. (ATRP). Their carrier abilities of different model compds. as well as active pharmaceutically ingredients in aq. solns. were evaluated by UV/Vis and 1H NMR spectroscopy studies. The highest loading capacities (up to 36 guest mols. per mol. of polymer) were, as expected, found for the 6-arm star-shaped polymers. The densely grafted poly[poly(ethylene glycol)methyl ether methacrylate] [p(mPEGMA)] shell stabilizes the host-guest complexes preventing undesired multimol. aggregation. Dynamic light scattering (DLS) measurements evidenced the unimol. character of all 4- and 6-arm polymers before and after loading with guest mols. The (bio)degradability of the core was demonstrated under acidic conditions and in vitro using a lipase from Rhizopus Arrhizus. The dual-stimuli responsiveness of the hydrophobic core to enzymes and pH may facilitate increased control over in vivo drug release. [on SciFinder (R)]
Original languageEnglish
Pages (from-to)1662-1667
JournalSoft Matter
Volume5
Issue number8
DOIs
Publication statusPublished - 2009

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Polymers
drugs
polymers
Pharmaceutical Preparations
Stars
rhizopus
Methyl Ethers
Methacrylates
Atom transfer radical polymerization
Polymethyl Methacrylate
Dynamic light scattering
Lipase
ingredients
stimuli
coronas
Nuclear magnetic resonance spectroscopy
Polyethylene glycols
enzymes
glycols
ethers

Cite this

Schramm, O. G., Meier, M. A. R., Hoogenboom, R., Erp, van, H. H. P., Gohy, J. M. W., & Schubert, U. S. (2009). Polymeric nanocontainers with high loading capacity of hydrophobic drugs. Soft Matter, 5(8), 1662-1667. https://doi.org/10.1039/b816087b
Schramm, O.G. ; Meier, M.A.R. ; Hoogenboom, R. ; Erp, van, H.H.P ; Gohy, J.M.W. ; Schubert, U.S. / Polymeric nanocontainers with high loading capacity of hydrophobic drugs. In: Soft Matter. 2009 ; Vol. 5, No. 8. pp. 1662-1667.
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Schramm, OG, Meier, MAR, Hoogenboom, R, Erp, van, HHP, Gohy, JMW & Schubert, US 2009, 'Polymeric nanocontainers with high loading capacity of hydrophobic drugs', Soft Matter, vol. 5, no. 8, pp. 1662-1667. https://doi.org/10.1039/b816087b

Polymeric nanocontainers with high loading capacity of hydrophobic drugs. / Schramm, O.G.; Meier, M.A.R.; Hoogenboom, R.; Erp, van, H.H.P; Gohy, J.M.W.; Schubert, U.S.

In: Soft Matter, Vol. 5, No. 8, 2009, p. 1662-1667.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Polymeric nanocontainers with high loading capacity of hydrophobic drugs

AU - Schramm, O.G.

AU - Meier, M.A.R.

AU - Hoogenboom, R.

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AU - Gohy, J.M.W.

AU - Schubert, U.S.

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AB - Water sol. 4- and 6-arm star-shaped polymers with (bio)degradable hydrophobic cores and dense hydrophilic coronas were synthesized by a combination of ring opening polymn. (ROP) and atom transfer radical polymn. (ATRP). Their carrier abilities of different model compds. as well as active pharmaceutically ingredients in aq. solns. were evaluated by UV/Vis and 1H NMR spectroscopy studies. The highest loading capacities (up to 36 guest mols. per mol. of polymer) were, as expected, found for the 6-arm star-shaped polymers. The densely grafted poly[poly(ethylene glycol)methyl ether methacrylate] [p(mPEGMA)] shell stabilizes the host-guest complexes preventing undesired multimol. aggregation. Dynamic light scattering (DLS) measurements evidenced the unimol. character of all 4- and 6-arm polymers before and after loading with guest mols. The (bio)degradability of the core was demonstrated under acidic conditions and in vitro using a lipase from Rhizopus Arrhizus. The dual-stimuli responsiveness of the hydrophobic core to enzymes and pH may facilitate increased control over in vivo drug release. [on SciFinder (R)]

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Schramm OG, Meier MAR, Hoogenboom R, Erp, van HHP, Gohy JMW, Schubert US. Polymeric nanocontainers with high loading capacity of hydrophobic drugs. Soft Matter. 2009;5(8):1662-1667. https://doi.org/10.1039/b816087b