Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 577-590 |
| Number of pages | 14 |
| Journal | Macromolecular Bioscience |
| Volume | 12 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2012 |
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Polymer-based scaffold designs for in situ vascular tissue engineering : controlling recruitment and differentiation behavior of endothelial colony forming cells. / Fioretta, E.S.; Fledderus, Joost; Burakowska-Meise, E.A.; Baaijens, F.P.T.; Verhaar, M.C.; Bouten, C.V.C.
In: Macromolecular Bioscience, Vol. 12, No. 5, 2012, p. 577-590.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Polymer-based scaffold designs for in situ vascular tissue engineering : controlling recruitment and differentiation behavior of endothelial colony forming cells
AU - Fioretta, E.S.
AU - Fledderus, Joost
AU - Burakowska-Meise, E.A.
AU - Baaijens, F.P.T.
AU - Verhaar, M.C.
AU - Bouten, C.V.C.
PY - 2012
Y1 - 2012
N2 - In situ vascular tissue engineering has been proposed as a promising approach to fulfill the need for small-diameter blood vessel substitutes. The approach comprises the use of a cell-free instructive scaffold to guide and control cell recruitment, differentiation, and tissue formation at the locus of implantation. Here we review the design parameters for such scaffolds, with special emphasis on differentiation of recruited ECFCs into the different lineages that constitute the vessel wall. Next to defining the target properties of the vessel, we concentrate on the target cell source, the ECFCs, and on the environmental control of the fate of these cells within the scaffold. The prospects of the approach are discussed in the light of current technical and biological hurdles.
AB - In situ vascular tissue engineering has been proposed as a promising approach to fulfill the need for small-diameter blood vessel substitutes. The approach comprises the use of a cell-free instructive scaffold to guide and control cell recruitment, differentiation, and tissue formation at the locus of implantation. Here we review the design parameters for such scaffolds, with special emphasis on differentiation of recruited ECFCs into the different lineages that constitute the vessel wall. Next to defining the target properties of the vessel, we concentrate on the target cell source, the ECFCs, and on the environmental control of the fate of these cells within the scaffold. The prospects of the approach are discussed in the light of current technical and biological hurdles.
U2 - 10.1002/mabi.201100315
DO - 10.1002/mabi.201100315
M3 - Article
C2 - 22566363
VL - 12
SP - 577
EP - 590
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
SN - 1616-5187
IS - 5
ER -