Physiologic-insensitive Left Ventricular Assist Predisposes Right-sided Circulatory Failure: a Pilot Simulation and Validation Study

K.D. Reesink; A.L.A.J. Dekker; T. Nagel, van der; J.A. Blom; C. Soemers; G.G. Geskes; J.G. Maessen; E. Veen, van der

doi:10.1111/j.1525-1594.2004.07380.x

Physiologic-insensitive Left Ventricular Assist Predisposes Right-sided Circulatory Failure: a Pilot Simulation and Validation Study

K.D. Reesink
, A.L.A.J. Dekker
, T. Nagel, van der
, J.A. Blom
, C. Soemers
, G.G. Geskes
, J.G. Maessen
, E. Veen, van der

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

1 Downloads (Pure)

Abstract

Right-sided circulatory failure (RSCF) is a serious complication in 15–30% of patients receiving a left ventricular assist device (LVAD). It is hypothesized that left ventricular support which lacks physiologic properties predisposes to RSCF. An integral computer simulation and experimental validation protocol was performed. The results suggest that with conventional insensitive left ventricular support right-sided circulatory function is compromised, which may form a substrate for the onset or progress of RSCF. Feedback control of the LVAD could provide a means to counter this problem. A control concept for the LVAD which aims to preserve right-sided circulatory function, while supporting peripheral perfusion, is proposed

Original language	English
Pages (from-to)	933-939
Number of pages	7
Journal	Artificial Organs
Volume	28
Issue number	10
DOIs	https://doi.org/10.1111/j.1525-1594.2004.07380.x
Publication status	Published - 2004

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title = "Physiologic-insensitive Left Ventricular Assist Predisposes Right-sided Circulatory Failure: a Pilot Simulation and Validation Study",

abstract = "Right-sided circulatory failure (RSCF) is a serious complication in 15{\textendash}30\% of patients receiving a left ventricular assist device (LVAD). It is hypothesized that left ventricular support which lacks physiologic properties predisposes to RSCF. An integral computer simulation and experimental validation protocol was performed. The results suggest that with conventional insensitive left ventricular support right-sided circulatory function is compromised, which may form a substrate for the onset or progress of RSCF. Feedback control of the LVAD could provide a means to counter this problem. A control concept for the LVAD which aims to preserve right-sided circulatory function, while supporting peripheral perfusion, is proposed",

author = "K.D. Reesink and A.L.A.J. Dekker and \{Nagel, van der\}, T. and J.A. Blom and C. Soemers and G.G. Geskes and J.G. Maessen and \{Veen, van der\}, E.",

year = "2004",

doi = "10.1111/j.1525-1594.2004.07380.x",

language = "English",

volume = "28",

pages = "933--939",

journal = "Artificial Organs",

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TY - JOUR

T1 - Physiologic-insensitive Left Ventricular Assist Predisposes Right-sided Circulatory Failure: a Pilot Simulation and Validation Study

AU - Reesink, K.D.

AU - Dekker, A.L.A.J.

AU - Nagel, van der, T.

AU - Blom, J.A.

AU - Soemers, C.

AU - Geskes, G.G.

AU - Maessen, J.G.

AU - Veen, van der, E.

PY - 2004

Y1 - 2004

N2 - Right-sided circulatory failure (RSCF) is a serious complication in 15–30% of patients receiving a left ventricular assist device (LVAD). It is hypothesized that left ventricular support which lacks physiologic properties predisposes to RSCF. An integral computer simulation and experimental validation protocol was performed. The results suggest that with conventional insensitive left ventricular support right-sided circulatory function is compromised, which may form a substrate for the onset or progress of RSCF. Feedback control of the LVAD could provide a means to counter this problem. A control concept for the LVAD which aims to preserve right-sided circulatory function, while supporting peripheral perfusion, is proposed

AB - Right-sided circulatory failure (RSCF) is a serious complication in 15–30% of patients receiving a left ventricular assist device (LVAD). It is hypothesized that left ventricular support which lacks physiologic properties predisposes to RSCF. An integral computer simulation and experimental validation protocol was performed. The results suggest that with conventional insensitive left ventricular support right-sided circulatory function is compromised, which may form a substrate for the onset or progress of RSCF. Feedback control of the LVAD could provide a means to counter this problem. A control concept for the LVAD which aims to preserve right-sided circulatory function, while supporting peripheral perfusion, is proposed

U2 - 10.1111/j.1525-1594.2004.07380.x

DO - 10.1111/j.1525-1594.2004.07380.x

M3 - Article

SN - 0160-564X

VL - 28

SP - 933

EP - 939

JO - Artificial Organs

JF - Artificial Organs

IS - 10

ER -

Physiologic-insensitive Left Ventricular Assist Predisposes Right-sided Circulatory Failure: a Pilot Simulation and Validation Study

Abstract

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