Physiologic-insensitive Left Ventricular Assist Predisposes Right-sided Circulatory Failure: a Pilot Simulation and Validation Study

K.D. Reesink, A.L.A.J. Dekker, T. Nagel, van der, J.A. Blom, C. Soemers, G.G. Geskes, J.G. Maessen, E. Veen, van der

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

Right-sided circulatory failure (RSCF) is a serious complication in 15–30% of patients receiving a left ventricular assist device (LVAD). It is hypothesized that left ventricular support which lacks physiologic properties predisposes to RSCF. An integral computer simulation and experimental validation protocol was performed. The results suggest that with conventional insensitive left ventricular support right-sided circulatory function is compromised, which may form a substrate for the onset or progress of RSCF. Feedback control of the LVAD could provide a means to counter this problem. A control concept for the LVAD which aims to preserve right-sided circulatory function, while supporting peripheral perfusion, is proposed
Original languageEnglish
Pages (from-to)933-939
Number of pages7
JournalArtificial Organs
Volume28
Issue number10
DOIs
Publication statusPublished - 2004

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