Physicochemical properties and applications of poly(lactic-co-glycolic acid) for use in bone regeneration

R.P. Félix Lanao, Anika M. Jonker, J.G.C. Wolke, John A. Jansen, J.C.M. Hest, van, S.C.G. Leeuwenburgh

Research output: Contribution to journalReview articleAcademicpeer-review

71 Citations (Scopus)

Abstract

Poly(lactic-co-glycolic acid) (PLGA) is the most often used synthetic polymer within the field of bone regeneration owing to its biocompatibility and biodegradability. As a consequence, a large number of medical devices comprising PLGA have been approved for clinical use in humans by the American Food and Drug Administration. As compared with the homopolymers of lactic acid poly(lactic acid) and poly(glycolic acid), the co-polymer PLGA is much more versatile with regard to the control over degradation rate. As a material for bone regeneration, the use of PLGA has been extensively studied for application and is included as either scaffolds, coatings, fibers, or micro-and nanospheres to meet various clinical requirements.

Original languageEnglish
Pages (from-to)380-390
Number of pages11
JournalTissue Engineering. Part B, reviews
Volume19
Issue number4
DOIs
Publication statusPublished - 1 Aug 2013
Externally publishedYes

Fingerprint Dive into the research topics of 'Physicochemical properties and applications of poly(lactic-co-glycolic acid) for use in bone regeneration'. Together they form a unique fingerprint.

  • Cite this