Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

Alexander V. Nyuchev, Ting Wan, Borja Cendón, Carlo Sambiagio, Job J.C. Struijs, Michelle Ho, Moisés Gulías, Ying Wang, Timothy Noël (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
29 Downloads (Pure)


The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was demonstrated to increase the reaction yield under batch conditions.

Original languageEnglish
Pages (from-to)1305-1312
Number of pages8
JournalBeilstein Journal of Organic Chemistry
Publication statusPublished - 15 Jun 2020


  • Continuous-flow
  • C–H functionalization
  • Organic synthesis
  • Photoredox catalysis
  • Trifluoromethoxylation


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