Photocatalytic modification of amino acids, peptides, and proteins

Cecilia Bottecchia, Timothy Noël (Corresponding author)

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)
103 Downloads (Pure)

Abstract

In the last decade, visible-light photoredox catalysis has emerged as a powerful strategy to enable novel transformations in organic synthesis. Owing to mild reaction conditions (i.e., room temperature, use of visible light) and high functional-group tolerance, photoredox catalysis could represent an ideal strategy for chemoselective biomolecule modification. Indeed, a recent trend in photoredox catalysis is its application to the development of novel methodologies for amino acid modification. Herein, an up-to-date overview of photocatalytic methodologies for the modification of single amino acids, peptides, and proteins is provided. The advantages offered by photoredox catalysis and its suitability in the development of novel biocompatible methodologies are described. In addition, a brief consideration of the current limitations of photocatalytic approaches, as well as future challenges to be addressed, are discussed.

Original languageEnglish
Pages (from-to)26-42
Number of pages17
JournalChemistry : A European Journal
Volume25
Issue number1
DOIs
Publication statusPublished - 2 Jan 2019

Keywords

  • amino acids
  • bioconjugation
  • peptides
  • photochemistry
  • redox chemistry
  • Oxidation-Reduction
  • Alanine/analogs & derivatives
  • Amino Acids/chemistry
  • Peptides/chemistry
  • Methionine/chemistry
  • Proteins/chemistry
  • Light
  • Tryptophan/chemistry
  • Catalysis
  • Cysteine/chemistry

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