Photoactivated Polymersome Nanomotors: Traversing Biological Barriers

Jingxin Shao; Shoupeng Cao; David S. Williams; Loai K.E.A. Abdelmohsen; Jan C.M. van Hest

doi:10.1002/anie.202003748

Photoactivated Polymersome Nanomotors: Traversing Biological Barriers

Jingxin Shao, Shoupeng Cao, David S. Williams, Loai K.E.A. Abdelmohsen (Corresponding author), Jan C.M. van Hest (Corresponding author)

Research output: Contribution to journal › Article › Academic › peer-review

100 Citations (Scopus)

Abstract

Synthetic nanomotors are appealing delivery vehicles for the dynamic transport of functional cargo. Their translation toward biological applications is limited owing to the use of non-degradable components. Furthermore, size has been an impediment owing to the importance of achieving nanoscale (ca. 100 nm) dimensions, as opposed to microscale examples that are prevalent. Herein, we present a hybrid nanomotor that can be activated by near-infrared (NIR)-irradiation for the triggered delivery of internal cargo and facilitated transport of external agents to the cell. Utilizing biodegradable poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) block copolymers, with the two blocks connected via a pH sensitive imine bond, we generate nanoscopic polymersomes that are then modified with a hemispherical gold nanocoat. This Janus morphology allows such hybrid polymersomes to undergoing photothermal motility in response to thermal gradients generated by plasmonic absorbance of NIR irradiation, with velocities ranging up to 6.2±1.10 μm s⁻¹. These polymersome nanomotors (PNMs) are capable of traversing cellular membranes allowing intracellular delivery of molecular and macromolecular cargo.

Original language	English
Pages (from-to)	16918-16925
Number of pages	8
Journal	Angewandte Chemie - International Edition
Volume	59
Issue number	39
Early online date	13 Jun 2020
DOIs	https://doi.org/10.1002/anie.202003748
Publication status	Published - 21 Sept 2020

Funding

We acknowledge the financial support by the ERC Advanced Grant Artisym 694120, the Dutch Ministry of Education, Culture and Science (Gravitation program 024.001.035) and the European Union's Horizon 2020 research and innovation programme Marie Sklodowska-Curie Innovative Training Networks (ITN) Nanomed (No. 676137). We thank the Ser Cymru II programme for support of D.S.W.; this project received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 663830. We acknowledge the financial support by the ERC Advanced Grant Artisym 694120, the Dutch Ministry of Education, Culture and Science (Gravitation program 024.001.035) and the European Union's Horizon 2020 research and innovation programme Marie Sklodowska‐Curie Innovative Training Networks (ITN) Nanomed (No. 676137). We thank the Ser Cymru II programme for support of D.S.W.; this project received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska‐Curie grant agreement No. 663830.

Funders	Funder number
European Union's Horizon 2020 - Research and Innovation Framework Programme	663830, 694120
Marie Skłodowska‐Curie
European Commission
H2020 European Research Council
Ministerie van Onderwijs, Cultuur en Wetenschap	024.001.035
European Union's Horizon 2020 - Research and Innovation Framework Programme	676137

Keywords

intracellular delivery
nanomotors
pH-sensitive polymer
photothermal effect
polymersomes

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abstract = "Synthetic nanomotors are appealing delivery vehicles for the dynamic transport of functional cargo. Their translation toward biological applications is limited owing to the use of non-degradable components. Furthermore, size has been an impediment owing to the importance of achieving nanoscale (ca. 100 nm) dimensions, as opposed to microscale examples that are prevalent. Herein, we present a hybrid nanomotor that can be activated by near-infrared (NIR)-irradiation for the triggered delivery of internal cargo and facilitated transport of external agents to the cell. Utilizing biodegradable poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) block copolymers, with the two blocks connected via a pH sensitive imine bond, we generate nanoscopic polymersomes that are then modified with a hemispherical gold nanocoat. This Janus morphology allows such hybrid polymersomes to undergoing photothermal motility in response to thermal gradients generated by plasmonic absorbance of NIR irradiation, with velocities ranging up to 6.2±1.10 μm s−1. These polymersome nanomotors (PNMs) are capable of traversing cellular membranes allowing intracellular delivery of molecular and macromolecular cargo.",

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Photoactivated Polymersome Nanomotors: Traversing Biological Barriers

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