Phase transfer catalysis in a microchannel: fluidic control of conversion and selectivity

J. Jovanovic, E.V. Rebrov, T.A. Nijhuis, V. Hessel, J.C. Schouten

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Abstract

Precise control over the segmented flow in a microchannel reactor offers an important tool for the optimization of reaction yield and productivity. The fluidic control over the reaction was demonstrated on the selective alkylation of benzyl cyanide to the monoalkylated product in a 250 µm microchannel reactor. The conversion of benzyl cyanide increased from 39.9% to 99.7% as a result of a 97% larger slug surface-to-volume ratio when the volumetric aqueous-to-organic phase flow ratio was raised from 1.0 to 6.1 at the same residence time. Conversion and selectivity in the microchannel reactor are both significantly larger than in a stirred reactor.
Original languageEnglish
Title of host publicationProceedings 21st International Symposium on Chemical Reaction Engineering (ISCRE-21), June 13-16, 2010, Philadelphia, PA, USA
Pages39-
Publication statusPublished - 2010
Event21st International Symposium on Chemical Reaction Engineering (ISCRE 21) - Philadelphia, PA, United States
Duration: 13 Jun 201016 Jun 2010

Conference

Conference21st International Symposium on Chemical Reaction Engineering (ISCRE 21)
Abbreviated titleISCRE 21
CountryUnited States
CityPhiladelphia, PA
Period13/06/1016/06/10

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    Jovanovic, J., Rebrov, E. V., Nijhuis, T. A., Hessel, V., & Schouten, J. C. (2010). Phase transfer catalysis in a microchannel: fluidic control of conversion and selectivity. In Proceedings 21st International Symposium on Chemical Reaction Engineering (ISCRE-21), June 13-16, 2010, Philadelphia, PA, USA (pp. 39-)