Pharmacokinetics of galanthamine (a long-acting anticholinesterase drug) in anaesthetized patients

P. Westra, M.J.S. Thiel, van, G.A. Vermeer, A.M. Soeterbroek, A.H.J. Scaf, H.A. Claessens

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Abstract

The pharmacokinetics of the long-acting anticholinesterase drug, galanthamine, were investigated in eight patients. After i.v. injection of 0.3 mg kg-1, the decrease in the serum concentration of galanthamine followed a biexponential curve. The serum concentration decreased rapidly from 543 +/- 47 ng ml-1 to 128 +/- 14 ng ml-1 between 2 and 30 min with a T1/2 alpha of 6.42 +/- 2.15 min, and then declined more slowly with a T1/2 beta of 264 +/- 28 min. Total serum clearance of galanthamine amounted to 5.37 +/- 0.87 ml min-1 kg-1, and the renal clearance was 1.36 +/- 0.10 ml min-1 kg-1. The cumulative urinary excretion of galanthamine between 0 and 48 h after injection amounted to 28.0 +/- 5.4% of the administered dose. The biliary excretion of galanthamine during 24 h amounted to 0.2 +/- 0.1% of the dose. There was no evidence of glucuronide or sulphate conjugation of galanthamine.
Original languageEnglish
Pages (from-to)1303-1307
JournalBritish Journal of Anaesthesia
Volume58
Issue number11
DOIs
Publication statusPublished - 1986

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Galantamine
Cholinesterase Inhibitors
Pharmacokinetics
Serum
Injections
Glucuronides
Sulfates
Kidney

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Westra, P., Thiel, van, M. J. S., Vermeer, G. A., Soeterbroek, A. M., Scaf, A. H. J., & Claessens, H. A. (1986). Pharmacokinetics of galanthamine (a long-acting anticholinesterase drug) in anaesthetized patients. British Journal of Anaesthesia, 58(11), 1303-1307. https://doi.org/10.1093/bja/58.11.1303
Westra, P. ; Thiel, van, M.J.S. ; Vermeer, G.A. ; Soeterbroek, A.M. ; Scaf, A.H.J. ; Claessens, H.A. / Pharmacokinetics of galanthamine (a long-acting anticholinesterase drug) in anaesthetized patients. In: British Journal of Anaesthesia. 1986 ; Vol. 58, No. 11. pp. 1303-1307.
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abstract = "The pharmacokinetics of the long-acting anticholinesterase drug, galanthamine, were investigated in eight patients. After i.v. injection of 0.3 mg kg-1, the decrease in the serum concentration of galanthamine followed a biexponential curve. The serum concentration decreased rapidly from 543 +/- 47 ng ml-1 to 128 +/- 14 ng ml-1 between 2 and 30 min with a T1/2 alpha of 6.42 +/- 2.15 min, and then declined more slowly with a T1/2 beta of 264 +/- 28 min. Total serum clearance of galanthamine amounted to 5.37 +/- 0.87 ml min-1 kg-1, and the renal clearance was 1.36 +/- 0.10 ml min-1 kg-1. The cumulative urinary excretion of galanthamine between 0 and 48 h after injection amounted to 28.0 +/- 5.4{\%} of the administered dose. The biliary excretion of galanthamine during 24 h amounted to 0.2 +/- 0.1{\%} of the dose. There was no evidence of glucuronide or sulphate conjugation of galanthamine.",
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Westra, P, Thiel, van, MJS, Vermeer, GA, Soeterbroek, AM, Scaf, AHJ & Claessens, HA 1986, 'Pharmacokinetics of galanthamine (a long-acting anticholinesterase drug) in anaesthetized patients', British Journal of Anaesthesia, vol. 58, no. 11, pp. 1303-1307. https://doi.org/10.1093/bja/58.11.1303

Pharmacokinetics of galanthamine (a long-acting anticholinesterase drug) in anaesthetized patients. / Westra, P.; Thiel, van, M.J.S.; Vermeer, G.A.; Soeterbroek, A.M.; Scaf, A.H.J.; Claessens, H.A.

In: British Journal of Anaesthesia, Vol. 58, No. 11, 1986, p. 1303-1307.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Pharmacokinetics of galanthamine (a long-acting anticholinesterase drug) in anaesthetized patients

AU - Westra, P.

AU - Thiel, van, M.J.S.

AU - Vermeer, G.A.

AU - Soeterbroek, A.M.

AU - Scaf, A.H.J.

AU - Claessens, H.A.

PY - 1986

Y1 - 1986

N2 - The pharmacokinetics of the long-acting anticholinesterase drug, galanthamine, were investigated in eight patients. After i.v. injection of 0.3 mg kg-1, the decrease in the serum concentration of galanthamine followed a biexponential curve. The serum concentration decreased rapidly from 543 +/- 47 ng ml-1 to 128 +/- 14 ng ml-1 between 2 and 30 min with a T1/2 alpha of 6.42 +/- 2.15 min, and then declined more slowly with a T1/2 beta of 264 +/- 28 min. Total serum clearance of galanthamine amounted to 5.37 +/- 0.87 ml min-1 kg-1, and the renal clearance was 1.36 +/- 0.10 ml min-1 kg-1. The cumulative urinary excretion of galanthamine between 0 and 48 h after injection amounted to 28.0 +/- 5.4% of the administered dose. The biliary excretion of galanthamine during 24 h amounted to 0.2 +/- 0.1% of the dose. There was no evidence of glucuronide or sulphate conjugation of galanthamine.

AB - The pharmacokinetics of the long-acting anticholinesterase drug, galanthamine, were investigated in eight patients. After i.v. injection of 0.3 mg kg-1, the decrease in the serum concentration of galanthamine followed a biexponential curve. The serum concentration decreased rapidly from 543 +/- 47 ng ml-1 to 128 +/- 14 ng ml-1 between 2 and 30 min with a T1/2 alpha of 6.42 +/- 2.15 min, and then declined more slowly with a T1/2 beta of 264 +/- 28 min. Total serum clearance of galanthamine amounted to 5.37 +/- 0.87 ml min-1 kg-1, and the renal clearance was 1.36 +/- 0.10 ml min-1 kg-1. The cumulative urinary excretion of galanthamine between 0 and 48 h after injection amounted to 28.0 +/- 5.4% of the administered dose. The biliary excretion of galanthamine during 24 h amounted to 0.2 +/- 0.1% of the dose. There was no evidence of glucuronide or sulphate conjugation of galanthamine.

U2 - 10.1093/bja/58.11.1303

DO - 10.1093/bja/58.11.1303

M3 - Article

VL - 58

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JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

SN - 0007-0912

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