Phage display selection of miniprotein binders of the Estrogen Receptor

T. Phan, H. Nguyen, H. Göksel, S. Möcklinghoff, L. Brunsveld

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)
2 Downloads (Pure)

Abstract

Miniprotein phage display screening yields structured peptides with high affinity for the Estrogen Receptor (ER). Hits from apamin phage libraries feature a LXXLL motif specifically placed on the predefined miniprotein helical segment. The apamin scaffold also allows optimization of flanking amino acids to ensure an optimal ER binding affinity
Original languageEnglish
Pages (from-to)8207-8209
JournalChemical Communications
Volume46
Issue number43
DOIs
Publication statusPublished - 2010

Fingerprint Dive into the research topics of 'Phage display selection of miniprotein binders of the Estrogen Receptor'. Together they form a unique fingerprint.

Cite this