TY - JOUR
T1 - Persistence-driven durotaxis
T2 - generic, directed motility in rigidity gradients
AU - Novikova, E.A.
AU - Raab, M.
AU - Discher, D.E.
AU - Storm, C.
PY - 2017/2/17
Y1 - 2017/2/17
N2 - Cells move differently on substrates with different rigidities: the persistence time of their motion is higher on stiffer substrates. We show that this behavior—in and of itself—results in a net flux of cells directed up a soft-to-stiff gradient. Using simple random walk models with varying persistence and stochastic simulations, we characterize the propensity to move in terms of the durotactic index also measured in experiments. A one-dimensional model captures the essential features and highlights the competition between diffusive spreading and linear, wavelike propagation. Persistence-driven durokinesis is generic and may be of use in the design of instructive environments for cells and other motile, mechanosensitive objects.
AB - Cells move differently on substrates with different rigidities: the persistence time of their motion is higher on stiffer substrates. We show that this behavior—in and of itself—results in a net flux of cells directed up a soft-to-stiff gradient. Using simple random walk models with varying persistence and stochastic simulations, we characterize the propensity to move in terms of the durotactic index also measured in experiments. A one-dimensional model captures the essential features and highlights the competition between diffusive spreading and linear, wavelike propagation. Persistence-driven durokinesis is generic and may be of use in the design of instructive environments for cells and other motile, mechanosensitive objects.
UR - http://www.scopus.com/inward/record.url?scp=85013347217&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.118.078103
DO - 10.1103/PhysRevLett.118.078103
M3 - Article
C2 - 28256894
VL - 118
SP - 1
EP - 5
JO - Physical Review Letters
JF - Physical Review Letters
SN - 0031-9007
IS - 7
M1 - 078103
ER -