Persistence-driven durotaxis: generic, directed motility in rigidity gradients

E.A. Novikova, M. Raab, D.E. Discher, C. Storm

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)
237 Downloads (Pure)

Abstract

Cells move differently on substrates with different rigidities: the persistence time of their motion is higher on stiffer substrates. We show that this behavior—in and of itself—results in a net flux of cells directed up a soft-to-stiff gradient. Using simple random walk models with varying persistence and stochastic simulations, we characterize the propensity to move in terms of the durotactic index also measured in experiments. A one-dimensional model captures the essential features and highlights the competition between diffusive spreading and linear, wavelike propagation. Persistence-driven durokinesis is generic and may be of use in the design of instructive environments for cells and other motile, mechanosensitive objects.
Original languageEnglish
Article number078103
Pages (from-to)1-5
JournalPhysical Review Letters
Volume118
Issue number7
DOIs
Publication statusPublished - 17 Feb 2017

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