Perinatal risk indicators for long-term neurological morbidity among preterm neonates

Dutch POPS-19 Collaborative Study Group, Peter Andriessen (Contributor)

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)
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OBJECTIVE: Many obstetric interventions are performed to improve long-term neonatal outcome. However, long-term neonatal outcome is usually not a primary outcome because it is time-consuming and expensive. The aim of this project was to identify different perinatal risk indicators and to develop prediction models for neurologic morbidity at 2 and 5 years of age.

STUDY DESIGN: Data from a Dutch cohort study of preterm and small-for-gestational-age infants was used. Neonates who were born in The Netherlands in 1983 with a gestational age of <34 weeks and without congenital abnormalities were included (n = 753). Infants were divided in 3 groups: no handicap, minor handicap, and major handicap.

RESULTS: Common risk indicators for major handicaps at 2 and 5 years of age were male sex (odds ratio, 2.7 and 3.0, respectively), seizures after ≥2 days of life (odds ratio, 5.8 and 5.8, respectively), and intracranial hemorrhage (odds ratio, 3.8 and 2.6, respectively).

CONCLUSION: In this cohort, male sex, intracranial hemorrhage, and seizures seem to be important risk indicators for long-term neurologic morbidity.

Original languageEnglish
Pages (from-to)396.e1-396.e14
Number of pages14
JournalAmerican Journal of Obstetrics and Gynecology
Issue number5
Publication statusPublished - May 2011
Externally publishedYes


  • Child, Preschool
  • Cohort Studies
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Small for Gestational Age
  • Male
  • Nervous System Diseases/diagnosis
  • Risk Factors


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