Peptide-mediated blood-brain barrier transport of polymersomes

J.V. Georgieva; R.P. Brinkhuis; Katica Stojanov; C.A.G.M. Weijers; H. Zuilhof; F.P.J.T. Rutjes; Dick Hoekstra; J.C.M. Hest, van; I.S. Zuhorn

doi:10.1002/anie.201202001

Peptide-mediated blood-brain barrier transport of polymersomes

J.V. Georgieva
, R.P. Brinkhuis
, Katica Stojanov
, C.A.G.M. Weijers
, H. Zuilhof
, F.P.J.T. Rutjes
, Dick Hoekstra
, J.C.M. Hest, van
, I.S. Zuhorn

Research output: Contribution to journal › Article › Academic › peer-review

106 Citations (Scopus)

Abstract

A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood-brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood-brain barrier transport is unprecedented.

Original language	English
Pages (from-to)	8339-8342
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	33
DOIs	https://doi.org/10.1002/anie.201202001
Publication status	Published - 13 Aug 2012
Externally published	Yes

Keywords

bioorganic chemistry
blood-brain barrier
drug delivery
peptides
polymersomes

Access to Document

10.1002/anie.201202001

Cite this

@article{14482cbdb9614eaba243f2d60007c0f0,

title = "Peptide-mediated blood-brain barrier transport of polymersomes",

abstract = "A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood-brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood-brain barrier transport is unprecedented.",

keywords = "bioorganic chemistry, blood-brain barrier, drug delivery, peptides, polymersomes",

author = "J.V. Georgieva and R.P. Brinkhuis and Katica Stojanov and C.A.G.M. Weijers and H. Zuilhof and F.P.J.T. Rutjes and Dick Hoekstra and \{Hest, van\}, J.C.M. and I.S. Zuhorn",

year = "2012",

month = aug,

day = "13",

doi = "10.1002/anie.201202001",

language = "English",

volume = "51",

pages = "8339--8342",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "Wiley",

number = "33",

}

TY - JOUR

T1 - Peptide-mediated blood-brain barrier transport of polymersomes

AU - Georgieva, J.V.

AU - Brinkhuis, R.P.

AU - Stojanov, Katica

AU - Weijers, C.A.G.M.

AU - Zuilhof, H.

AU - Rutjes, F.P.J.T.

AU - Hoekstra, Dick

AU - Hest, van, J.C.M.

AU - Zuhorn, I.S.

PY - 2012/8/13

Y1 - 2012/8/13

N2 - A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood-brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood-brain barrier transport is unprecedented.

AB - A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood-brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood-brain barrier transport is unprecedented.

KW - bioorganic chemistry

KW - blood-brain barrier

KW - drug delivery

KW - peptides

KW - polymersomes

UR - https://www.scopus.com/pages/publications/84864875659

U2 - 10.1002/anie.201202001

DO - 10.1002/anie.201202001

M3 - Article

C2 - 22786792

AN - SCOPUS:84864875659

SN - 1433-7851

VL - 51

SP - 8339

EP - 8342

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 33

ER -

Peptide-mediated blood-brain barrier transport of polymersomes

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this