Peptide-mediated blood-brain barrier transport of polymersomes

J.V. Georgieva; R.P. Brinkhuis; Katica Stojanov; C.A.G.M. Weijers; H. Zuilhof; F.P.J.T. Rutjes; Dick Hoekstra; J.C.M. Hest, van; I.S. Zuhorn

doi:10.1002/anie.201202001

Peptide-mediated blood-brain barrier transport of polymersomes

J.V. Georgieva, R.P. Brinkhuis, Katica Stojanov, C.A.G.M. Weijers, H. Zuilhof, F.P.J.T. Rutjes, Dick Hoekstra, J.C.M. Hest, van, I.S. Zuhorn

Research output: Contribution to journal › Article › Academic › peer-review

101 Citations (Scopus)

Abstract

A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood-brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood-brain barrier transport is unprecedented.

Original language	English
Pages (from-to)	8339-8342
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	33
DOIs	https://doi.org/10.1002/anie.201202001
Publication status	Published - 13 Aug 2012
Externally published	Yes

Keywords

bioorganic chemistry
blood-brain barrier
drug delivery
peptides
polymersomes

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10.1002/anie.201202001

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AU - Georgieva, J.V.

AU - Brinkhuis, R.P.

AU - Stojanov, Katica

AU - Weijers, C.A.G.M.

AU - Zuilhof, H.

AU - Rutjes, F.P.J.T.

AU - Hoekstra, Dick

AU - Hest, van, J.C.M.

AU - Zuhorn, I.S.

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AB - A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood-brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood-brain barrier transport is unprecedented.

KW - bioorganic chemistry

KW - blood-brain barrier

KW - drug delivery

KW - peptides

KW - polymersomes

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 33

ER -

Peptide-mediated blood-brain barrier transport of polymersomes

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Keywords

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