Peptide-mediated blood-brain barrier transport of polymersomes

J.V. Georgieva, R.P. Brinkhuis, Katica Stojanov, C.A.G.M. Weijers, H. Zuilhof, F.P.J.T. Rutjes, Dick Hoekstra, J.C.M. Hest, van, I.S. Zuhorn

Research output: Contribution to journalArticleAcademicpeer-review

82 Citations (Scopus)

Abstract

A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood-brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood-brain barrier transport is unprecedented.

Original languageEnglish
Pages (from-to)8339-8342
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number33
DOIs
Publication statusPublished - 13 Aug 2012
Externally publishedYes

Keywords

  • bioorganic chemistry
  • blood-brain barrier
  • drug delivery
  • peptides
  • polymersomes

Fingerprint

Dive into the research topics of 'Peptide-mediated blood-brain barrier transport of polymersomes'. Together they form a unique fingerprint.

Cite this