Patient-specific models of wall stress in abdominal aortic aneurysm : A comparison between MR and CT

Sander De Putter, Marcel Breeuwer, Frans N. Van De Vosse, Ursula Kose, Frans A. Gerritsen

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)

Abstract

Finite element method based patient-specific wall stress in abdominal aortic: anemysm (AAA) may provide a more accurate rupture risk predictor than the currently used maximum transverse diameter. In this study, we have investigated the sensitivity of the wall stress in AAA with respect to geometrical variations. We have acquired MR and CT images for four patients with AAA. Three individual users have delineated the AAA vessel wall contours on the image slices. These contours were used to generate synthetic feature images for a cleformable model based segmentation method. We investigated the reproducibility and the influence of the user variability on the wall stress. For sufficiently smooth models of the AAA wall, the peak wall stress is reproducible for three out of the four AAA geometries. The 0.99 percentiles of the wall stress show excellent reproducibility for all four AAAs. The variations induced by user variability are larger than the errors caused by the segmentation variability. The influence of the user variability appears to be similar for MR and CT. We conclude that the peak wall stress in AAA is sensitive to small geometrical variations. To increase reproducibility it appears to be best not to allow too much geometrical detail in the simulations. This could be achieved either by using a sufficiently smooth geometry representation or by using a more robust statistical parameter derived from the wall stress distribution.

Original languageEnglish
Title of host publicationMedical Imaging 2006
Subtitle of host publicationPhysiology, Function, and Structure from Medical Images
Place of PublicationBellingham
PublisherSPIE
Number of pages12
ISBN (Print)0819461865, 9780819461865
DOIs
Publication statusPublished - 30 Jun 2006
EventMedical Imaging 2006: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: 12 Feb 200614 Feb 2006

Publication series

NameProceedings of SPIE
Volume6143
ISSN (Print)0277-786X

Conference

ConferenceMedical Imaging 2006: Physiology, Function, and Structure from Medical Images
CountryUnited States
CitySan Diego, CA
Period12/02/0614/02/06

Keywords

  • Abdominal aortic aneurysm
  • CT
  • MR
  • Sensitivity analysis
  • Wall stress

Fingerprint Dive into the research topics of 'Patient-specific models of wall stress in abdominal aortic aneurysm : A comparison between MR and CT'. Together they form a unique fingerprint.

Cite this