Pathway dependent shape-transformation of azide-decorated polymersomes

Hailong Che; Lafayette N.J. de Windt; Jianzhi Zhu; Imke A.B. Pijpers; Alexander F. Mason; Loai K.E.A. Abdelmohsen; Jan C.M. van Hest

doi:10.1039/c9cc08944f

Pathway dependent shape-transformation of azide-decorated polymersomes

Hailong Che, Lafayette N.J. de Windt, Jianzhi Zhu, Imke A.B. Pijpers, Alexander F. Mason, Loai K.E.A. Abdelmohsen (Corresponding author), Jan C.M. van Hest (Corresponding author)

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Abstract

Here we report the shape transformation of poly(ethylene glycol)-polystyrene (PEG-PS) polymersomes into ordered inverse morphologies, directed by the salt concentration of the medium and the presence of azide groups on the polymersome surface. The azide moieties introduced at the chain ends of the PEG blocks induce a difference in hydrodynamic volume of the hydrophilic domains at the inner and outer side of the vesicular membrane, allowing control over its spontaneous curvature and hence the pathway of shape deformation. This simple modification enables access to intricate morphologies which are traditionally only accessible via the application of complex polymer building blocks.

Original language	English
Pages (from-to)	2127-2130
Number of pages	4
Journal	Chemical Communications, ChemComm
Volume	56
Issue number	14
DOIs	https://doi.org/10.1039/c9cc08944f
Publication status	Published - 18 Feb 2020

Funding

The authors acknowledge the Dutch Science Foundation (VICI grant), the ERC Advanced grant Artisym 694120, the Dutch Ministry of Education, Culture and Science (Gravitation program 024.001.035) and the European Union’s Horizon 2020 research and innovation programme Marie Sklodowska Curie Innovative Training Network Nanomed, (No. 676137) for funding.

Funders	Funder number
Horizon 2020 Framework Programme	676137, 694120
H2020 European Research Council
Ministerie van Onderwijs, Cultuur en Wetenschap	024.001.035
Nederlandse Organisatie voor Wetenschappelijk Onderzoek

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AU - Zhu, Jianzhi

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AU - Mason, Alexander F.

AU - Abdelmohsen, Loai K.E.A.

AU - van Hest, Jan C.M.

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Pathway dependent shape-transformation of azide-decorated polymersomes

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