Paramagnetic lipid-coated silica nanoparticles with a fluorescent quantum dot core: A new contrast agent platform for multimodality imaging

R. Koole, M.M. Schooneveld, van, J. Hilhorst, Karolien Castermans, D.P. Cormode, G.J. Strijkers, C. Mello Donegá, de, D. Vanmaekelbergh, A.W. Griffioen, K. Nicolay, Z.A. Fayad, A. Meijerink, W.J.M. Mulder

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    138 Citations (Scopus)
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    Abstract

    Silica particles as a nanoparticulate carrier material for contrast agents have received considerable attention the past few years, since the material holds great promise for biomedical applications. A key feature for successful application of this material in vivo is biocompatibility, which may be significantly improved by appropriate surface modification. In this study, we report a novel strategy to coat silica particles with a dense monolayer of paramagnetic and PEGylated lipids. The silica nanoparticles carry a quantum dot in their center and are made target-specific by the conjugation of multiple avß3-integrin-specific RGD-peptides. We demonstrate their specific uptake by endothelial cells in vitro using fluorescence microscopy, quantitative fluorescence imaging, and magnetic resonance imaging. The lipid-coated silica particles introduced here represent a new platform for nanoparticulate multimodality contrast agents.
    Original languageEnglish
    Pages (from-to)2471-2479
    JournalBioconjugate Chemistry
    Volume19
    Issue number12
    DOIs
    Publication statusPublished - 2008

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