TY - JOUR
T1 - Palladium-catalyzed aerobic oxidative coupling of o-Xylene in flow
T2 - A Safe and Scalable Protocol for Cross-Dehydrogenative Coupling
AU - Erdmann, N.
AU - Su, Y.
AU - Bosmans, B.L.
AU - Hessel, V.
AU - Noël, T.
PY - 2016/4/15
Y1 - 2016/4/15
N2 - Herein, the first continuous cross-dehydrogenative homocoupling of an unactivated arene using oxygen as sole oxidant is reported. Employing microreactor technology which enables the use of elevated temperatures and pressures leads to a boost of the catalytic reaction. Hence, a major reduction in reaction time is achieved. Due to the significance as precursor for MOFs as well as high-tech and high-value polymers, the study focused on the production of 3,4,3′,4′-tetramethyl-biphenyl.
AB - Herein, the first continuous cross-dehydrogenative homocoupling of an unactivated arene using oxygen as sole oxidant is reported. Employing microreactor technology which enables the use of elevated temperatures and pressures leads to a boost of the catalytic reaction. Hence, a major reduction in reaction time is achieved. Due to the significance as precursor for MOFs as well as high-tech and high-value polymers, the study focused on the production of 3,4,3′,4′-tetramethyl-biphenyl.
UR - http://www.scopus.com/inward/record.url?scp=84966350737&partnerID=8YFLogxK
U2 - 10.1021/acs.oprd.6b00044
DO - 10.1021/acs.oprd.6b00044
M3 - Article
AN - SCOPUS:84966350737
SN - 1083-6160
VL - 20
SP - 831
EP - 835
JO - Organic Process Research & Development
JF - Organic Process Research & Development
IS - 4
ER -