Osteoinductive ceramics as a synthetic alternative to autologous bone grafting

Huipin Yuan, Hugo Fernandes, Pamela Habibovic, Jan De Boer, Ana M.C. Barradas, Ad De Ruiter, William R. Walsh, Clemens A. Van Blitterswijk, Joost D. De Bruijn

Research output: Contribution to journalArticleAcademicpeer-review

614 Citations (Scopus)


Biomaterials can be endowed with biologically instructive properties by changing basic parameters such as elasticity and surface texture. However, translation from in vitro proof of concept to clinical application is largely missing. Porous calcium phosphate ceramics are used to treat small bone defects but in general do not induce stem cell differentiation, which is essential for regenerating large bone defects. Here, we prepared calcium phosphate ceramics with varying physicochemical and structural characteristics. Microporosity correlated to their propensity to stimulate osteogenic differentiation of stem cells in vitro and bone induction in vivo. Implantation in a large bone defect in sheep unequivocally demonstrated that osteoinductive ceramics are equally efficient in bone repair as autologous bone grafts. Our results provide proof of concept for the clinical application of "smart" biomaterials.

Original languageEnglish
Pages (from-to)13614-13619
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America (PNAS)
Issue number31
Publication statusPublished - 3 Aug 2010
Externally publishedYes


  • Bone morphogenetic proteins
  • Mesenchymal stromal cells
  • Osteoinduction
  • Surface topography
  • Tricalcium phosphate


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